Drug interactions with Vyvanse vs. Adderall

Vyvanse

Monoamine oxidase inhibitor (MAOIs) antidepressants such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl) and procarbazine (Matulane), slow the elimination of amphetamines in the body. This increases the concentration of amphetamines and their effect. This can cause serious elevations in blood pressure (hypertensive crisis) with headaches, other signs of hypertensive crisis, and even fatal reactions. Vyvanse should not be administered until 14 days after MAOIs have been discontinued in order to allow the effects of the MAOIs to dissipate. Amphetamines increase the effect of norepinephrine. Combining both drugs may lead to seriouscardiovascular toxicity.

Adderall

As with Vyvanse, Adderall should not be taken with monoamine oxidase (MAO) inhibitor drugs including phenelzine (Nardil), tranylcypromine (Parnate), and Zyvox; use of amphetamine within 14 days of using MAO inhibitor drugs should be avoided. Patients receiving antihypertensive medications may experience loss of blood pressure control with amphetamine. Antacids may increase absorption of amphetamine salts and increase their effectiveness and side effects.

Pregnancy and breastfeeding safety for Vyvanse vs. Adderall

Vyvanse

There are no adequate studies of Vyvanse in pregnant women. Amphetamines may cause premature delivery, low birth weight, and withdrawal symptoms in infants born to mothers who are dependent on amphetamines.

Amphetamines are excreted in breast milk. Mothers taking amphetamines should not breastfeed.

Adderall

As with Vyvanse, Adderall should not be used during pregnancy. Infants who are born to mothers dependent on amphetamines exhibit symptoms of withdrawal and have an increased risk of low birth weight.

Mothers taking amphetamines should refrain from nursing their infants because these drugs are excreted in human milk and can have undesirable effects on the child.

FDA Prescribing Information

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