vortioxetine (Trintellix - formerly known as Brintellix)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

What is vortioxetine, and how does it work (mechanism of action)?

  • Vortioxetine (Brintellix) is an antidepressant used for treating a certain type of depression known as major depressive disorder (MDD). Vortioxetine decreases the reuptake of serotonin just like selective serotonin reuptake inhibitors (SSRIs). It also stimulates various serotonin receptors in the brain.
  • The exact mechanism by which vortioxetine helps to improve mood in patients a major depressive disorder is not known. It may have a role in enhancing the activity of the neurotransmitter serotonin in the brain by inhibiting the transport of serotonin. Additionally, vortioxetine appears to block or stimulate some serotonin receptors. The exact contribution of the respective activity of vortioxetine at these receptor sites remain to be understood.
  • Vortioxetine was approved by the FDA in September 2013.

What brand names are available for vortioxetine?

Trintellix (formerly known as Brintellix)

Is vortioxetine available as a generic drug?


Do I need a prescription for vortioxetine?


What are the uses for vortioxetine?

Vortioxetine is used for the treatment of a certain type of depression known as major depressive disorder (MDD).

What are the side effects of vortioxetine?

The most common side effects of vortioxetine treatment are:

Medically Reviewed by a Doctor on 7/1/2016

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