vitamin K-1, phytonadione (Mephyton)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

Take the Blood Disorders Quiz

What is vitamin k-injection, and how does it work (mechanism of action)?

Phytonadione is a synthetic form of vitamin K that is chemically identically to the naturally occurring vitamin K. Vitamin K is found in many foods from both plant and animal sources. Common sources of vitamin K include green leafy vegetables such as

  • broccoli,
  • Brussels sprouts,
  • collard greens,
  • lettuce, and
  • spinach.

Vitamin K plays a crucial role in blood coagulation and the formation of blood clots. Vitamin K is necessary for the production of clotting factors in the liver including active prothrombin (factory II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X). The FDA approved phytonadione 1940.

What brand names are available for vitamin k-injection?

Mephyton

Is vitamin k-injection available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for vitamin k-injection?

No

What are the side effects of vitamin k-injection?

Serious hypersensitivity reactions, including anaphylactoid reactions and death have been reported with use of injectable phytonadione. The majority of these cases were associated with use of intravenous phytonadione.

Other side effects reported with use of injectable phytonadione include:

Hyperbilirubinemia (high levels of bilirubin in the blood), a byproduct of red blood cell breakdown, has been reported in newborns following administration of injectable phytonadione.

What is the dosage for vitamin k-injection?

Oral vitamin K in Adults

  • For the treatment of anticoagulant-induced prothrombin deficiency: The initial recommended dose is 2.5 mg to 10 mg or up to 25 mg by mouth (rarely 50 mg).
  • For the treatment of hypoprothrombinemia due to other causes: the initial recommended dose is 2.5 mg to 25 mg or more (rarely up to 50 mg).
  • For the treatment of bleeding or bleeding prophylaxis in patients with warfarin toxicity: Adults with INR > 10 with no significant bleeding: administer 2.5-5 mg by mouth. Hold warfarin therapy.
  • Adults with serious bleeding at any elevation of INR: administer 5-10 mg intravenously by slow infusion in combination with 4-factor prothrombin complex concentrate. Hold warfarin therapy.
  • For the treatment of hemorrhagic disease of the newborn: administer 1 mg/dose/day intramuscularly (into the muscle) or subcutaneously (into the fatty tissue). Higher doses may be required if mother has been receiving treatment with oral anticoagulants.
  • For the prevention of hemorrhagic disease of the newborn: administer 0.5-1 mg intramuscularly within 1 hour of birth.

Which drugs or supplements interact with vitamin k-injection?

Phytonadione antagonizes or blocks the therapeutic benefits of warfarin (Coumadin) treatment. Warfarin inhibits vitamin K reductase, the enzyme responsible for reducing vitamin K. The reduced form of vitamin K is used by the liver to make blood clotting factors. When phytonadione is given to treat or prevent warfarin induced bleeding, a temporary resistance to warfarin may develop. Risk of resistance is higher with use of large doses of phytonadione.

Is vitamin k-injection safe to take if I'm pregnant or breastfeeding?

It is not known if phytonadione is excreted into human milk. Because many drugs can enter breast milk and cause harm to the nursing infant, phytonadione should be used cautiously in nursing mothers.

What else should I know about vitamin k-injection?

What preparations of vitamin k-injection are available?

  • Oral tablets: 5 mg, 100 mcg
  • Solution for injection: 10 mg/ml, 1 mg/0.5 ml

How should I keep vitamin k-injection stored?

Tablets should be stored at room temperature between 15 C and 30 C (59 F and 86 F). Injectable vitamin K should be stored in original container at controlled room temperature between 20 C and 25 C (68 F and 77 F), and should be protected from light.

REFERENCE: FDA Prescribing Information.

Subscribe to MedicineNet's General Health Newsletter

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Reviewed on 6/12/2015
References
REFERENCE: FDA Prescribing Information.

Health Solutions From Our Sponsors