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If you have a condition such as heart disease or diabetes, or a history of heart attack or stroke, don't take doses of 400 IU/day or more. Some research suggests that high doses might increase the chance of death from all causes and possibly cause other serious side effects. The higher the dose, the greater the risk of serious side effects.
There is contradictory information about the effect of vitamin E on the chance of developing prostate cancer. Some research suggests that taking large amounts of a multivitamin plus a separate vitamin E supplement might actually increase the chance of developing prostate cancer in some men.
High doses can also cause nausea, diarrhea, stomach cramps, fatigue, weakness, headache, blurred vision, rash, and bruising and bleeding.
When used in the recommended daily amount vitamin E is considered safe for pregnant and breast-feeding women. However, don't take higher amounts without the advice of your healthcare professional.
Do not use vitamin E if:
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.