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Vitamin A is POSSBILY UNSAFE when taken by mouth in high doses. Some scientific research suggests that higher doses might increase the risk of osteoporosis and hip fracture, particularly in older people. Adults who eat low-fat dairy products, which are fortified with vitamin A, and a lot of fruits and vegetables usually do not need vitamin A supplements or multivitamins that contain vitamin A.
Long-term use of large amounts of vitamin A might cause serious side effects including fatigue, irritability, mental changes, anorexia, stomach discomfort, nausea, vomiting, mild fever, excessive sweating, and many other side effects. In women who have passed menopause, taking too much vitamin A can increase the risk of osteoporosis and hip fracture.
There is growing concern that taking high doses of antioxidant supplements such as vitamin A might do more harm than good. Some research shows that taking high doses of vitamin A supplements might increase the chance of death from all causes and possibly other serious side effects.
Vitamin A is LIKELY SAFE for children when taken in the recommended amounts. The maximum amounts of vitamin A that are safe for children are based on age:
Special Precautions & Warnings:Pregnancy and breast-feeding: Vitamin A is LIKELY SAFE for pregnant or breast-feeding women when taken in recommended amounts of less than 10,000 units per day. Larger amounts are POSSIBLY UNSAFE. Vitamin A can cause birth defects. It is especially important for pregnant women to monitor their intake of vitamin A from all sources during the first three months of pregnancy. Forms of vitamin A are found in several foods including animal products, primarily liver, some fortified breakfast cereals, and dietary supplements.
Excessive use of alcohol: Drinking alcohol may increase vitamin A's potentially harmful effects on the liver.
Disorders in which the body does not absorb fat properly: People with conditions that affect fat absorption, such as celiac disease, short gut syndrome, jaundice, cystic fibrosis, pancreatic disease, and cirrhosis of the liver, are not able to absorb vitamin A properly. To improve vitamin A absorption, these people should use vitamin A preparations that are water-soluble.
A type of high cholesterol called "Type V hyperlipoproteinemia:" This condition might increase the chance of vitamin A poisoning. Do not take vitamin A if you have this condition.
Intestinal infections: Intestinal infections such as hookworm can reduce how much vitamin A the body absorbs.
Liver disease: Too much vitamin A might make liver disease worse. Do not take vitamin A if you have liver disease.
Malnutrition: In people with severe protein malnutrition, taking vitamin A might result in having too much vitamin A in the body.
Zinc deficiency: Zinc deficiency might cause symptoms of vitamin A deficiency to occur. Taking a combination of vitamin A and zinc supplements might be necessary to improve this condition.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.