Viekira Pak (ombitasvir, paritaprevir, ritonavir, and dasabuvir)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is Viekira Pak, and how does it work (mechanism of action)?

Viekira Pak is a combination of drugs used to treat patients with hepatitis C virus (HCV) genotype 1. It contains four medicines, dasabuvir, ombitasvir, paritaprevir, and ritonavir. Viekira Pak belongs to a class of drugs called direct-acting antiviral agents. Similar drugs include

Dasabuvir, ombitasvir, and paritaprevir are antivirals that work in three different ways to help stop HCV from multiplying. They block the effect of proteases which are enzymes that HCV uses for making new virus, leading to reduced numbers of HCV copies in the body. Ombitasvir blocks HCV NS5A protease while paritaprevir blocks HCV NS3/4A protease. Dasabuvir blocks a viral structure called NS5B palm polymerase which is also needed for replication of HCV. Ritonavir is not active against the HCV virus. It is used to increase blood levels of paritaprevir by inhibiting the breakdown of paritaprevir.

In clinical studies Viekira Pak, with or without ribavirin (Rebetol) HCV was cured in 95% to 100% of patients treated. Cure was defined as undetectable levels of HCV in the blood 3 months after treatment. The FDA approved Viekira Pak in December 2014.

What brand names are available for Viekira Pak?

Viekira Pak

Is Viekira Pak available as a generic drug?


Do I need a prescription for Viekira Pak?


What are the side effects of Viekira Pak?

The most common side effects of Viekira Pak when used with ribavirin include

The most common side effects of Viekira Pak when used without ribavirin include

  • nausea,
  • itching, and
  • problems sleeping.

Other side effects include

  • allergic reactions,
  • anemia, and
  • increases in liver enzymes and bilirubin.

Medically Reviewed by a Doctor on 8/14/2015

Quick GuideHepatitis C (Hep C) Symptoms and Treatment

Hepatitis C (Hep C) Symptoms and Treatment
FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

RxList Logo

Need help identifying pills and medications?

Use the pill identifier tool on RxList.

Subscribe to MedicineNet's Newsletters

Get the latest health and medical information delivered direct to your inbox!

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

Health Solutions From Our Sponsors