venlafaxine, Effexor; Effexor XR (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Combining venlafaxine with aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin (Coumadin) or other drugs that are associated with bleeding may increase the risk of bleeding, because venlafaxine is associated with bleeding.

Most medications affecting the brain such as venlafaxine have the potential to slow reflexes or impair judgment. Therefore, caution is advised especially early in the course of treatment.

Safety has not been established in children below the age of 18 years.

PREGNANCY: The effects of venlafaxine on the fetus during pregnancy are unknown.

NURSING MOTHERS: It is not known if venlafaxine is secreted in breast milk, and therefore, if it may have an effect on nursing infants.

SIDE EFFECTS: Venlafaxine, like most anti-depressants, can cause nausea, headaches, anxiety, insomnia, drowsiness, and loss of appetite. Dizziness, ejaculation disorder, sweating, dry mouth, and weight loss also may occur. Increased blood pressure can occur, and blood pressure should be monitored. Seizures have been reported.

The FDA suggests if anti-depressants are discontinued abruptly, symptoms may occur such as dizziness, headache, nausea, changes in mood, or changes in the sense of smell, taste, etc. (Such symptoms even may occur when even a few doses of anti-depressant are missed.) Therefore, it is generally recommended that the dose of anti-depressant be reduced gradually when therapy is discontinued.

Antidepressants increased the risk of suicidal thinking and behavior (suicidality) in short-term studies in children, adolescents, and young adults with depression and other psychiatric disorders. Anyone considering the use of venlafaxine or any other antidepressant in a child or adolescent must balance this risk with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidality, or unusual changes in behavior.

Reference: FDA Prescribing Information


Medically Reviewed by a Doctor on 7/7/2014


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