vardenafil, Levitra, Staxyn ODT (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
PREPARATIONS: Tablets: 2.5, 5, 10 and 20 mg. Tablet (orally disintegrating): 10 mg.
STORAGE: Vardenafil should be stored at room temperature between 15-30 C (59-86 F).
PRESCRIBED FOR: Vardenafil is used for the treatment of impotence.
DOSING: For most individuals, the recommended dose of vardenafil regular tablets is 10 mg per day taken 60 minutes before intercourse. If there is no response or side effects, the dose may be increased to 20 mg or, if there are side effects, it may be reduced to 5 mg.
Individuals 65 years of age or older should begin therapy with 5 mg.
Individuals who are taking medications that increase the blood levels of vardenafil should start treatment with 2.5 to 5 mg of vardenafil. (See drug interactions.)
Orally disintegrating tablets (ODT) are not interchangeable with regular vardenafil tablets because they are better absorbed and produce higher blood levels than regular tablets. The recommended dosing when using ODT is one tablet 60 minutes before intercourse. Only one tablet should be used per day. It should be placed on the tongue until it disintegrates and should not be swallowed with water.
DRUG INTERACTIONS: The breakdown and elimination of vardenafil from the body is inhibited by erythromycin, clarithromycin (Biaxin), ketoconazole (Nizoral), itraconazole (Sporanox), indinavir (Crixivan), ritonavir (Norvir), atazanavir (Reyataz), grapefruit juice. Therefore, these drugs increase the concentration of vardenafil in the blood and should not be combined with vardenafil. Vardenafil reduces the concentration of ritonavir and indinavir and may reduce the effect these drugs. Vardenafil increases heart rate and also exaggerates blood pressure lowering effects of nitrates (for example, nitroglycerine). In patients with chest pain (angina), particularly those who take nitrates,, vardenafil can cause chest pain by increasing heart rate and lowering blood pressure. Therefore, patients with angina should not use vardenafil. Vardenafil also exaggerates the blood pressure lowering effects of alpha-blocking drugs, for example, terazosin (Hytrin), and should not be used by individuals who also use alpha-blockers. Vardenafil also adds to the blood pressure reducing effect of other medications.
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