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February 8, 2012

Vancomycin-Resistant Enterococci

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Vancomycin-Resistant Enterococci Precautions

What precautions should caregivers take when tending to infected persons in their homes?

Outside of healthcare settings, there is little risk of becoming infected with VRE. In the home, the following precautions should be taken:

  • Caregivers should wash their hands with soap and water after physical contact with the infected or colonized person, and before leaving the home.


  • Towels used for drying hands after contact should be used only once.


  • Disposable gloves should be worn if contact with body fluids is expected, and hands should be washed after removing the gloves.


  • Linens should be changed and washed on a routine basis, and if they are soiled.


  • The patient's environment should be cleaned routinely, and when soiled with body fluids.


  • Notify doctors and other healthcare personnel, who provide care for patients, if an individual is colonized or infected with a multidrug-resistant organism.

SOURCE:

National Institute of Allergy and Infectious Diseases, National Institutes of Health

What are vancomycin-resistant enterococci (VRE)?

Enterococci are a group of gram-negative, round-shaped bacteria that commonly live in the gut, although they can cause infection anywhere in the body. They are resistant to several antibiotics, but in the past, physicians could rely on the drug vancomycin to effectively treat enterococcal infections. In recent decades, however, some enterococci have become resistant to vancomycin. The two main species that cause problems are vancomycin-resistant Enterococcus faecium and vancomycin-resistant Enterococcus faecalis, with E. faecium being the most common.

Vancomycin resistance is acquired when a sensitive Enterococcus acquires a special piece of DNA called a plasmid. The new strain is called vancomycin-resistant enterococci (VRE). One concern is that VRE appears able to transfer vancomycin resistance to unrelated bacteria such as MRSA (methicillin-resistant Staphylococcus aureus). In addition, VRE organisms are usually resistant to more than one antibiotic.

VRE can also be spread from person to person and are an increasing problem in hospitals and chronic-care facilities. Approximately 30% of all enterococcal infections are now caused by vancomycin-resistant strains (VRE).

What causes a vancomycin-resistant enterococcal (VRE) infection?

VRE can exist in the body without causing infection, in which case a patient is said to be colonized with VRE. Colonization usually occurs in the bowel. If the number of VRE bacteria increases, they can invade the bloodstream or spread locally to cause an abdominal abscess or urinary infection. Once in the bloodstream, VRE can cause meningitis, pneumonia, or infection of a heart valve (endocarditis). VRE may also be introduced directly into an open sore or wound, causing a wound infection. The bacteria produce several substances, including proteases that help them break down the normal barriers between the gut tissue and the bloodstream.



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