vancomycin, Vancocin

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Rare but serious side effects are

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Capsules: 125 and 250 mg. Oral powder: 25 and 50 mg compounding kit.

STORAGE: Tablets should be stored at room temperature, from 15 C to 30 C (59 F to 86 F).

DOSING:

C. difficile-associated diarrhea:

Adult (= 18 years): The recommended dose is one 125 mg administered 4 times daily for 10 days.

Pediatric (<18 years): The recommended dose is 40 mg/kg in 3 or 4 divided doses for 7 to 10 days. Total daily dose should not exceed 2 grams.

Staphylococcal enterocolitis:

Adult (= 18 years): The recommended total daily dosage is 500 mg to 2000 mg administered in 3 or 4 divided doses for 7 to 10 days.

Pediatric (<18 years): The recommended dose is 40 mg/kg in 3 or 4 divided doses for 7 to 10 days. Total daily dose should not exceed 2 grams.

DRUG INTERACTIONS: No drug interaction studies have been conducted for oral vancomycin.

PREGNANCY: Use of vancomycin in pregnancy has not been adequately evaluated. Due to the lack of safety data, vancomycin should be used in pregnancy only if clearly needed. Oral vancomycin is classified as FDA pregnancy risk category B. This designation indicates animal studies have shown no harm to the fetus, but adequate safety studies on pregnant women do not exist.

NURSING MOTHERS: Vancomycin is excreted in human milk after intravenous administration. However, oral administration of vancomycin does not result in significant levels of drug in the blood, and it is not known if vancomycin is excreted in breast milk after oral administration. Due to the lack of safety data, oral vancomycin should be used cautiously in nursing mothers.

REFERENCE: FDA Prescribing Information

Medically Reviewed by a Doctor on 4/22/2015

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