valsartan/hydrochlorothiazide (Diovan HCT)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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Patients allergic to sulfa may also be allergic to hydrochlorothiazide because of the similarity in the chemical structure of the two medications.

Hydrochlorothiazide can worsen kidney failure and is used with caution in patients with kidney disease.

Hydrochlorothiazide can lower blood potassium, sodium, and magnesium levels. Low potassium and magnesium levels can lead to abnormalities in heart rhythm, especially in patients already taking digoxin (Lanoxin). During hydrochlorothiazide treatment, supplementation with potassium is common to prevent low potassium levels.

Blood uric acid levels can increase during hydrochlorothiazide treatment, and this elevation may cause an episode of acute gout in some individuals.

Thiazide diuretics may increase blood sugar (glucose) levels and precipitate diabetes.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 80/12.5, 160/12.5, 160/25, 320/12.5, and 320 mg/25 mg

STORAGE: Valsartan/hydrochlorothiazide tablets should be stored between 15 C and 30 C (59 and 86 F).

DOSING: The recommended starting dose of valsartan/hydrochlorothiazide is 80/12.5 to 160 mg/ 12.5 mg by mouth once daily. If blood pressure is not controlled, doses may be increased every 1 to 2 weeks to a maximum of 320 mg/25 mg per day.

DRUG INTERACTIONS: Valsartan/hydrochlorothiazide can increase lithium (Lithobid, Eskolith) levels in the body. Patients may experience increased side effects of lithium like:

Medically Reviewed by a Doctor on 12/23/2014

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