- High Blood Pressure Slideshow Pictures
- Take the Salt Quiz!
- Lowering Blood Pressure Exercise Tips Pictures
- What is VALSARTAN W/ HYDROCHLOROTHIAZIDE-ORAL, and how does it work (mechanism of action)?
- What brand names are available for VALSARTAN W/ HYDROCHLOROTHIAZIDE-ORAL?
- Is VALSARTAN W/ HYDROCHLOROTHIAZIDE-ORAL available as a generic drug?
- Do I need a prescription for VALSARTAN W/ HYDROCHLOROTHIAZIDE-ORAL?
- What are the side effects of VALSARTAN W/ HYDROCHLOROTHIAZIDE-ORAL?
- What is the dosage for VALSARTAN W/ HYDROCHLOROTHIAZIDE-ORAL?
- Which drugs or supplements interact with VALSARTAN W/ HYDROCHLOROTHIAZIDE-ORAL?
- Is VALSARTAN W/ HYDROCHLOROTHIAZIDE-ORAL safe to take if I'm pregnant or breastfeeding?
- What else should I know about VALSARTAN W/ HYDROCHLOROTHIAZIDE-ORAL?
What is VALSARTAN W/ HYDROCHLOROTHIAZIDE-ORAL, and how does it work (mechanism of action)?
Valsartan/hydrochlorothiazide is a combination of two medications that is used to treat high blood pressure and congestive heart failure. It belongs to a class of drugs called angiotensin receptor blockers (ARBs) which also includes:
Angiotensin, formed in the blood by the action of angiotensin converting enzyme (ACE), is a powerful chemical that attaches to angiotensin receptors found in many tissues but primarily on smooth muscle cells surrounding blood vessels. Angiotensin's attachment to the receptors causes the muscles to contract and the blood vessels to narrow (vasoconstrict) which leads to an increase in blood pressure (hypertension). Valsartan blocks the angiotensin receptor. By blocking the action of angiotensin, valsartan dilates (widens) blood vessels and reduces blood pressure. Valsartan belongs to the class of drugs called ARBs or angiotensin II receptor blockers
Hydrochlorothiazide is a diuretic (water pill) used for treating high blood pressure and accumulation of fluid. It works by blocking salt and water reabsorption in the kidneys, thus causing increased output of urine containing increased amounts of water and salt (diuresis). The mechanism of its action in lowering high blood pressure is not well understood. The combination of valsartan and hydrochlorothiazide reduces blood pressure more that either drug alone.
The FDA approved valsartan/hydrochlorothiazide in March 1998.
What brand names are available for VALSARTAN W/ HYDROCHLOROTHIAZIDE-ORAL?
Is VALSARTAN W/ HYDROCHLOROTHIAZIDE-ORAL available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for VALSARTAN W/ HYDROCHLOROTHIAZIDE-ORAL?
What are the side effects of VALSARTAN W/ HYDROCHLOROTHIAZIDE-ORAL?
Side effect of valsartan/hydrochlorothiazide are the same as its individual components.
Valsartan is generally well-tolerated. The most common side effects of valsartan include:
Patients also may experience:
Rare but serious side effects of valsartan are:
- rhabdomyolysis (inflammation and destruction of muscle), and
- angioedema (swelling of soft tissues including those of the throat and larynx).
Quick GuideHow to Lower Blood Pressure: Exercise Tips
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Use the pill identifier tool on RxList.