valdecoxib, Bextra (cont.)

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PREPARATIONS: Oblong white tablets containing 10 or 20mg of valdecoxib.

STORAGE: Valdecoxib tablets should be stored at room temperature, 59-86 °F (15-30 °C).

PRESCRIBED FOR: Valdecoxib is used for the relief of pain, fever, swelling, and tenderness caused by osteoarthritis and rheumatoid arthritis, but it does not prevent the destruction of joints by the arthritis. Valdecoxib also is approved for the relief of pain of menstrual cramps (primary dysmenorrhea).

DOSING: For osteoarthritis or rheumatoid arthritis, the usual approved dose of valdecoxib is 10 mg once daily. For dysmenorrhea, the dose is 20 mg twice daily. Valdecoxib may be taken with or without food.

DRUG INTERACTIONS: NSAIDs can reduce the actions of diuretics such as furosemide (Lasix) and hydrochlorothiazide (Hydrodiuril) in some patients and lead to retention of water.

Fluconazole (Diflucan), ketoconazole (Nizoral), and lithium (Eskalith) may increase the concentration of valdecoxib in the body by inhibiting its breakdown in the liver.

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