valdecoxib, Bextra (cont.)

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Medical and Pharmacy Editor:

NURSING MOTHERS: The use of valdecoxib in nursing mothers has not been evaluated.

SIDE EFFECTS: The most common side effects of valdecoxib are headache, abdominal pain, diarrhea, nausea, flatulence and insomnia. Other side effects include fainting, kidney failure, heart failure, fluid retention, aggravation of hypertension, chest pain, ringing in the ears, deafness, stomach and intestinal ulcers, bleeding, blurred vision, anxiety, photosensitivity, weight gain, water retention, flu-like symptoms, drowsiness and weakness.

Very serious allergic reactions have been reported with valdecoxib. It is recommended that patients who experience a rash after beginning therapy with valdecoxib should discontinue valdecoxib immediately and seek the advise of their physician. Although valdecoxib is not a sulfonamide itself (unlike celecoxib), it is recommended that patients with an allergy to sulfonamides ("sulfas") should not take valdecoxib.

Although the chances of stomach or intestinal ulceration or bleeding with valdecoxib are low, a small risk of these side effects remains. Patients taking valdecoxib should report any symptoms or signs of ulceration or bleeding such as abdominal pain or black stools to their doctor

Reference: FDA Prescribing Information

Last Editorial Review: 4/7/2005

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