ursodiol, Actigall, Urso Forte, Urso 250 (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
DOSING: The recommended dose for dissolving gallstones in adults is 8-10 mg/kg/day split into two or three doses (every 8 or 12 hours). Each dose should not exceed 300 mg. The maintenance dose is 250 mg at bedtime for six months.
For treating primary biliary cirrhosis, the recommended dose is 13-15 mg/kg/day split into 2 to 4 doses. Ursodiol should be taken with meals.
DRUG INTERACTIONS: Aluminum containing antacids, cholestyramine (Questran, Questran Light) and colestipol (Colestid) reduce the absorption of ursodiol and therefore reduce its action. Estrogens, oral contraceptives, clofibrate, and potentially other cholesterol reducing drugs may counteract the effects of ursodiol by increasing cholesterol secretion by the liver and the risk for gallstone formation.
PREGNANCY: The are no adequate studies in pregnant women.
NURSING MOTHERS: It is not known whether ursodiol is secreted in breast milk.
SIDE EFFECTS: The most common side effects are rash, itching, nausea, vomiting, stomach pain, back pain, constipation, and diarrhea. Hair loss also may occur. Serious allergic reactions and reduced concentration of white blood cells also have occurred.
Reference: FDA Prescribing Information
Last Editorial Review: 5/4/2012
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