urokinase-injection, Abbokinase (cont.)

PRECAUTIONS: Tell your doctor if you have: pre-existing bleeding disorders, high blood pressure, heart infection (endocarditis), recent biopsy or surgery, recent injury, any allergies. Use extra caution to avoid injury and trauma (e.g., carefully brushing teeth) while using this medication due to the increased risk of bleeding. Consult your doctor regarding the unlikely risk that this drug contains infectious material. This medication should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Tell your doctor of any prescription or nonprescription medication you may take including: "blood thinners" (e.g., warfarin), NSAIDs (e.g., ibuprofen, naproxen), aspirin. Drugs that can reverse effects of urokinase include: aminocaproic acid, aprotinin, tranexamic acid. Aspirin or NSAID drugs (e.g., ibuprofen) should not be used to treat fever, since they may increase the chance of bleeding while using urokinase. Do not start or stop any medicine without doctor or pharmacist approval.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.

NOTES: Laboratory tests will be done frequently while using this medication to monitor its effects and to prevent side effects.

MISSED DOSE: Continued dosing is usually not necessary for this medication.

STORAGE: Store powder vial in refrigerator at 36-46 degrees F (2 to 8 degrees C). Reconstituted solution should be used immediately after reconstituting. Discard any unused portion.

Last Editorial Review: 3/2/2005

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