urokinase (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

DOSING: Administer a loading dose of 4400 international units per kg intravenously over 10 minutes, followed by a continuous administration of 4400 international units per kg per hour intravenously for 12 hours. Repeat as necessary.

Safe and effective use of urokinase is not established for children.

DRUG INTERACTIONS: Urokinase should be used with caution with other medications that alter platelet function and increase risk of bleeding. Medications like aspirin, ibuprofen (Motrin), naproxen (Aleve, Naprosyn), warfarin (Coumadin), enoxaparin (Lovenox), clopidogrel (Plavix), and cilostazol (Pletal) should be used with caution with urokinase.

PREGNANCY: There are no adequate studies done on urokinase to determine safe and effective use in pregnant women. Urokinase should be only used if clearly needed.

NURSING MOTHERS: It is not known whether urokinase enters breast milk. It is best to be cautious before using it in nursing mothers.

SIDE EFFECTS: Side effects of urokinase are bleeding, decreased hematocrit, chest pain, increased heart rate, fever, chills, nausea, vomiting, and anaphylaxis reactions.

REFERENCE: FDA Prescribing Information

Medically Reviewed by a Doctor on 10/7/2014

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.

Back to Medications Index

Health Solutions From Our Sponsors