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February 10, 2012
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urokinase-injection, Abbokinase

GENERIC NAME: UROKINASE - INJECTION (you-row-KYE-naze)

BRAND NAME(S): Abbokinase

Warning | Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage

WARNING: Internal bleeding may be more difficult to control with this medication than with other anticoagulant therapy. This medication must be used in a hospital setting. It should be started as soon as possible after lung blood clots have been noticed (pulmonary embolism), preferably within 7 days. Urokinase should be given within 6 hours of the first symptoms of a heart attack associated with evolving myocardial infarction.

USES: This medication is a protein (enzyme) which works to break up and dissolve blood clots which can block arteries. It is used in the treatment of very serious blood clots in lung blood vessels (pulmonary embolism).

HOW TO USE: This medication is given by injection by a health care professional. It is important this medication be used as prescribed. It is most effective when administered as soon as possible after symptoms appear (e.g., within 6 hours of onset of chest pain).

SIDE EFFECTS: Dizziness, fever, headache, or nausea may occur shortly after the drug is given by vein (infusion reaction). Notify the doctor immediately if any of these effects occur, as the drug infusion may need to be stopped, or medication to treat the reaction may need to be given. Notify your doctor immediately if you experience: easy bruising or bleeding (e.g., pink urine, bleeding gums, black or bloody stools), a rapid or abnormal heartbeat, chest pain, tingling or numbness of the hands/feet. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. Rare (possibly fatal) cholesterol blood clots (emboli) may occur while using medicines that dissolve blood clots. Report immediately any of the following symptoms: change in amount of urine, severe stomach/abdominal pain, unexplained muscle pain, discolored toes or fingers. If you notice other effects not listed above, contact your doctor or pharmacist.




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urokinase-injection, Abbokinase

Introduction to deep vein thrombosis (DVT)

Arteries have thin muscles within their walls to be able to withstand the pressure of the heart pumping blood to the far reaches of the body. Veins don't have a significant muscle lining, and there is nothing pumping blood back to the heart except physiology. Blood returns to the heart because the body's large muscles squeeze the veins as they contract in their normal activity of moving the body. The normal activities of moving the body returns the blood back to the heart.

There are two types of veins in the leg; superficial veins and deep veins. Superficial veins lie just below the skin and are easily seen on the surface. Deep veins, as their name implies, are located deep within the muscles of the leg. Blood flows from the superficial veins into the deep venous system through small perforator veins. Superficial and perforator veins have one-way valves within them that allow blood to flow only in the direc...

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