Typhoid vaccine live oral Ty21a, Vivotif (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

DOSING: The recommended dosing for adults and children 6 years of age and older is: Take 1 capsule by mouth one hour before a meal for 4 doses, on days 1, 3, 5, and 7. Use cold or lukewarm water and should not exceed body temperature 37 C (98.6 F).

  • Dosing should be completed at least 1 week prior to potential exposure.
  • A booster dose of 4 capsules is needed every 5 years if re-exposure is expected.

DRUG INTERACTIONS: Typhoid vaccine is not recommended for use with belimumab (Benlysta), ceftaroline (Taflaro), certolizumab pegol (Cimzia), hydroxyurea (Droxia), and methotrexate (Rheumatrex, Trexall) because they significantly lower the effectiveness of typhoid vaccine.

Typhoid vaccine should be used with caution with medications like azathioprine (Imuran, Azasan), etanercept (Enbrel), amoxicillin, cefprozil (Cefzil), budesonide (Entocort, Uceris ER), hydrocortisone, and triamcinolone because they lower beneficial effect of typhoid vaccine.

Anti-malaria drugs, such as mefloquine (Lariam), chloroquine (Aralen), and proguanil (Maralone) have anti-bacterial activity which may interfere with the immunogenicity of typhoid vaccine.

Medically Reviewed by a Doctor on 6/3/2014

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