Typhoid vaccine live oral Ty21a, Vivotif

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

What is the dosage for typhoid vaccine-oral enteric-coated capsule?

The recommended dosing for adults and children 6 years of age and older is: Take 1 capsule by mouth one hour before a meal for 4 doses, on days 1, 3, 5, and 7. Use cold or lukewarm water and should not exceed body temperature 37 C (98.6 F).

  • Dosing should be completed at least 1 week prior to potential exposure.
  • A booster dose of 4 capsules is needed every 5 years if re-exposure is expected.

Which drugs or supplements interact with typhoid vaccine-oral enteric-coated capsule?

Typhoid vaccine is not recommended for use with belimumab (Benlysta), ceftaroline (Taflaro), certolizumab pegol (Cimzia), hydroxyurea (Droxia), and methotrexate (Rheumatrex, Trexall) because they significantly lower the effectiveness of typhoid vaccine.

Typhoid vaccine should be used with caution with medications like azathioprine (Imuran, Azasan), etanercept (Enbrel), amoxicillin, cefprozil (Cefzil), budesonide (Entocort, Uceris ER), hydrocortisone, and triamcinolone because they lower beneficial effect of typhoid vaccine.

Anti-malaria drugs, such as mefloquine (Lariam), chloroquine (Aralen), and proguanil (Maralone) have anti-bacterial activity which may interfere with the immunogenicity of typhoid vaccine.

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