Typhoid vaccine live oral Ty21a, Vivotif

Pharmacy Author:
Medical and Pharmacy Editor:

GENERIC NAME: Typhoid vaccine live oral Ty21a

BRAND NAME: Vivotif

DRUG CLASS AND MECHANISM: Typhoid vaccine is a live attenuated (weakened) oral typhoid vaccine. Typhoid disease is caused by ingestion of Salmonella typhi strains from contaminated food or water. Active immunity from vaccine is occurs when the body produces antibodies to typhoid in response to the weakened typhoid bacteria in the vaccine. Oral typhoid vaccine produces a local response in the intestines, boosting immunity.

PRESCRIPTION: Yes

GENERIC AVAILABLE: No

PREPARATIONS: Typhoid vaccine is an enteric-coated capsule, containing viable and non-viable strains of Salmonella typhi Ty21a. It is available in a blister package of 4 capsules.

STORAGE: Store typhoid vaccine capsules between 2 C to 8 C (35.6 F to 46.4 F).

PRESCRIBED FOR: Typhoid vaccine is used for protection against typhoid fever in individuals 6 years of age and older who are travelers to areas which have a recognized risk of exposure to Salmonella typhi, or have intimate exposure (for example, household members) to a Salmonella typhi carrier or are microbiology laboratory employees who work frequently with Salmonella typhi.

DOSING: The recommended dosing for adults and children 6 years of age and older is: Take 1 capsule by mouth one hour before a meal for 4 doses, on days 1, 3, 5, and 7. Use cold or lukewarm water and should not exceed body temperature 37 C (98.6 F).

  • Dosing should be completed at least 1 week prior to potential exposure.
  • A booster dose of 4 capsules is needed every 5 years if re-exposure is expected.

DRUG INTERACTIONS: Typhoid vaccine is not recommended for use with belimumab (Benlysta), ceftaroline (Taflaro), certolizumab pegol (Cimzia), hydroxyurea (Droxia), and methotrexate (Rheumatrex, Trexall) because they significantly lower the effectiveness of typhoid vaccine.

Medically Reviewed by a Doctor on 6/3/2014



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.


Back to Medications Index