GENERIC NAME: Typhoid vaccine live oral Ty21a
BRAND NAME: Vivotif
DRUG CLASS AND MECHANISM: Typhoid vaccine is a live attenuated (weakened) oral typhoid vaccine. Typhoid disease is caused by ingestion of Salmonella typhi strains from contaminated food or water. Active immunity from vaccine is occurs when the body produces antibodies to typhoid in response to the weakened typhoid bacteria in the vaccine. Oral typhoid vaccine produces a local response in the intestines, boosting immunity.
GENERIC AVAILABLE: No
STORAGE: Store typhoid vaccine capsules between 2 C to 8 C (35.6 F to 46.4 F).
PRESCRIBED FOR: Typhoid vaccine is used for protection against typhoid fever in individuals 6 years of age and older who are travelers to areas which have a recognized risk of exposure to Salmonella typhi, or have intimate exposure (for example, household members) to a Salmonella typhi carrier or are microbiology laboratory employees who work frequently with Salmonella typhi.
DOSING: The recommended dosing for adults and children 6 years of age and older is: Take 1 capsule by mouth one hour before a meal for 4 doses, on days 1, 3, 5, and 7. Use cold or lukewarm water and should not exceed body temperature 37 C (98.6 F).
- Dosing should be completed at least 1 week prior to potential exposure.
- A booster dose of 4 capsules is needed every 5 years if re-exposure is expected.
DRUG INTERACTIONS: Typhoid vaccine is not recommended for use with belimumab (Benlysta), ceftaroline (Taflaro), certolizumab pegol (Cimzia), hydroxyurea (Droxia), and methotrexate (Rheumatrex, Trexall) because they significantly lower the effectiveness of typhoid vaccine.
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