trovafloxacin mesylate, Trovan

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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What is trovafloxacin mesylate, and how does it work (mechanism of action)?

Many common infections in humans are caused by single cell organisms, called bacteria. Bacteria can grow and multiply, infecting different parts of the body. Medicines that control and eradicate these bacteria are called antibiotics. Trovafloxacin is an antibiotic that stops multiplication of bacteria by preventing the reproduction and repair of their genetic material (DNA). It is among a class of antibiotics called fluoroquinolones, a class that includes ciprofloxacin (Cipro), norfloxacin (Noroxin), ofloxacin (Floxin), levofloxacin (Levaquin), and lomefloxacin (Maxaquin). Trovafloxacin was approved by the FDA in 1997.

Pfizer withdrew Trovan from Markets worldwide in 2001 because of the risk of fatal liver failure.

What brand names are available for trovafloxacin mesylate?

Trovan (Discontinued)

Is trovafloxacin mesylate available as a generic drug?

GENERIC AVAILABLE: No

Do I need a prescription for trovafloxacin mesylate?

Yes

What are the side effects of trovafloxacin mesylate?

The most frequently reported side effects associated with trovafloxacin include

Trovafloxacin as well as other antibiotics in the fluoroquinolone class of antibiotics, has been associated with tendinitis and even rupture of tendons, particularly the Achilles tendon. Some physicians recommend that their patients discontinue vigorous exercise while they are taking fluoroquinolone antibiotics.

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What is the dosage for trovafloxacin mesylate?

Trovafloxacin usually is given once daily, with or without food. It is important to take it at least 2 hours before or 2 hours after antacids or mineral supplements containing iron, calcium, zinc, or magnesium which bind the antibiotic and prevent its absorption.

Is trovafloxacin mesylate safe to take if I'm pregnant or breastfeeding?

Trovafloxacin is not recommended for use in pregnant women since trovafloxacin causes joint and bone deformities in juvenile animals of several species.

Trovafloxacin is not recommended for use in lactating women. Trovafloxacin causes joint and bone deformities in juvenile animals of several species. In fact, trovafloxacin is not recommended in persons under the age of 18 years.

What else should I know about trovafloxacin mesylate?

What preparations of trovafloxacin mesylate are available?

Tablets: 100mg (round; blue), 200mg (oval; blue)

How should I keep trovafloxacin mesylate stored?

Trovafloxacin should be stored below 86 F.

Medically reviewed by John Cunha, DO

Reference: FDA Prescribing Information

Last Editorial Review: 8/9/2017

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Reviewed on 8/9/2017
References
Medically reviewed by John Cunha, DO

Reference: FDA Prescribing Information

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