trovafloxacin mesylate, Trovan

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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GENERIC NAME: trovafloxacin mesylate

BRAND NAME: Trovan (Discontinued)

Pfizer withdrew Trovan from Markets worldwide in 2001 because of the risk of fatal liver failure.

DRUG CLASS AND MECHANISM: Many common infections in humans are caused by single cell organisms, called bacteria. Bacteria can grow and multiply, infecting different parts of the body. Medicines that control and eradicate these bacteria are called antibiotics. Trovafloxacin is an antibiotic that stops multiplication of bacteria by preventing the reproduction and repair of their genetic material (DNA). It is among a class of antibiotics called fluoroquinolones, a class that includes ciprofloxacin (Cipro), norfloxacin (Noroxin), ofloxacin (Floxin), levofloxacin (Levaquin), and lomefloxacin (Maxaquin). Trovafloxacin was approved by the FDA in 1997.

Pfizer withdrew Trovan from Markets worldwide in 2001 because of the risk of fatal liver failure.

GENERIC AVAILABLE: No

PRESCRIPTION: Yes

PREPARATIONS: Tablets: 100mg (round; blue), 200mg (oval; blue)

STORAGE: Trovafloxacin should be stored below 86 F.

PRESCRIBED FOR: Trovafloxacin is used to treat infections of the sinuses, skin, lungs, and airways caused by susceptible bacteria. Trovafloxacin also is frequently used to treat infections of the urine and prostate, including those infections caused by bacteria that are resistant to other antibiotics. Trovafloxacin also can be used to treat various obstetric infections.

DOSING: Trovafloxacin usually is given once daily, with or without food. It is important to take it at least 2 hours before or 2 hours after antacids or mineral supplements containing iron, calcium, zinc, or magnesium which bind the antibiotic and prevent its absorption.

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