trimipramine (Surmontil) (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
Hospitalized patients may receive up to 300 mg daily. This total daily dosage may be taken once daily at bedtime or spread throughout the day. Beneficial effects may not be seen until treatment at an appropriate dose is given for two to four weeks.
DRUG INTERACTIONS: Trimipramine increases the effects of other medications and drugs that slow the brain's processes, such as alcohol, barbiturates, benzodiazepines, for example, diazepam (Valium) or lorazepam (Ativan), zolpidem (Ambien) and narcotics. Reserpine, given to patients taking TCAs, can cause a stimulatory effect. Trimipramine and other TCAs should not be used with monoamine oxidase inhibiting drugs for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane). High fever, convulsions and even death can occur when these drugs are used together. Trimipramine affects heart rhythm. Therefore, trimipramine should not be administered with amiodarone (Cordarone), sotalol (Betapace), quinidine, procainamide, and other drugs that also affect heart rhythm.
PREGNANCY: Safe use of trimipramine during pregnancy has not been established; therefore, if it is to be administered to pregnant patients or women of childbearing potential, the benefits must be weighed against the potential hazards to the fetus.
NURSING MOTHERS: Safe use of trimipramine during lactation has not been established; therefore, if it is to be administered to nursing mothers, the benefits must be weighed against the potential hazards to the child.
SIDE EFFECTS: Trimipramine may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery. The anti-cholinergic effects of trimipramine may cause confusion, delirium, short-term memory problems, disorientation, impaired attention, dry mouth, constipation, difficulty urinating (especially in men with enlarged prostates), blurred vision, decreased sweating with increased body temperature, sexual dysfunction, and worsening of glaucoma. Older adults are especially sensitive to the anti-cholinergic effects of trimipramine.
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