trimipramine (Surmontil)

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GENERIC NAME: trimipramine

BRAND NAME: Surmontil

DRUG CLASS AND MECHANISM: Trimipramine is a tricyclic antidepressant (TCA) in the same family as amitriptyline (Elavil), imipramine (Tofranil), nortriptyline (Pamelor; Aventyl), and desipramine (Norpramin). Trimipramine works by raising the brain's level of norepinephrine (a neurotransmitter) to more normal levels. It also has anti-cholinergic actions (opposing the effects of the neurotransmitter, acetylcholine) which cause many of its side effects. Trimipramine also acts as a sedative. Trimipramine was approved by the FDA in June 1979.



PREPARATIONS: Capsules: 25, 50, and 100 mg

STORAGE: Capsules should be stored at room temperature, approximately 25 C (77 F).

PRESCRIBED FOR: Trimipramine is used for treating major depression.

DOSING: The usual starting dose for adults is 50 to 75 mg per day, split into equal, smaller doses (for example, 25 mg three times daily). Doses are gradually increased every 2 to 3 weeks.

Usual doses for long-term therapy may range from 50 to 150 milligrams daily and doses may be increase up to 200 mg per day if needed.

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