trimetrexate glucuronate-injection, Neutrexin (cont.)

SIDE EFFECTS: Fever, nausea, or fatigue may occur. If these effects continue or become bothersome, inform your doctor. Notify your doctor if you develop: mouth sores, unusual bruising or bleeding, weakness, skin rash, flu-like symptoms, breathing trouble, seizures, rapid/pounding/irregular heartbeat. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, breathing trouble. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor your medical history, especially of: kidney or liver problems, blood disorders, other illnesses (infections), any allergies you may have. Trimetrexate is not recommended for use during pregnancy. Consult your doctor before using this medication. It is not known if this drug passes into breast milk. Because the possibility exists this drug may harm a nursing infant, consult your doctor before breast-feeding.

DRUG INTERACTIONS: Tell your doctor of any over-the-counter or prescription medication you may take including: antibiotics, cimetidine, seizure medications. Do not start or stop any medicine without doctor or pharmacist approval.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include severe fatigue or unusual bleeding or busing.

NOTES: Leucovorin is a medication given by mouth or injection and must be administered along with trimetrexate and continued for 3 days after. Leucovorin prevents serious side effects of trimetrexate. Laboratory tests will be done periodically while taking this medication to monitor its effects and prevent side effects.

MISSED DOSE: It is important that each dose be taken as needed. If you miss a dose, take it as soon as remembered. Skip the missed dose. Do not "double-up" the dose to catch up.

STORAGE: Once prepared, this medication is stable at room temperature or under refrigeration for up to 24 hours. Check the expiration date on the label and properly discard of any unused medication after that time.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).

Last Editorial Review: 3/2/2005

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