- What is Primsol (trimethoprim)?
- What brand names are available for XYZ?
- Is Primsol (trimethoprim) available as a generic drug?
- Do I need a prescription for Primsol (trimethoprim)?
- What are the uses for Primsol (trimethoprim)?
- What are the side effects of Primsol (trimethoprim)?
- What is the dosage for Primsol (trimethoprim)?
- Which drugs or supplements interact with Primsol (trimethoprim)?
- Is Primsol (trimethoprim) safe to take during pregnancy or while breastfeeding?
- What else should I know about Primsol (trimethoprim)?
What is Primsol (trimethoprim) and how does it work?
Primsol is a synthetic (man-made) antibiotic that interferes with the production of tetrahydrofolic acid, a chemical that is necessary in order for bacteria and human cells to produce proteins. Trimethoprim inhibits production of tetrahydrofolic acid by inhibiting the enzyme responsible for making tetrahydrofolic acid from dihydrofolic acid. Primsol inhibits the bacterial enzyme more than the human enzyme. Therefore, Primsol has less effect on the production of tetrahydrofolic acid by humans. Because of the frequent development of resistance to Primsol, it is more effective when combined with another antibiotic, sulfamethoxazole (Azo-Gantanol), and is rarely used alone.
What brand names are available for XYZ?
- Primsol is the brand name for trimethoprim available in the US.
- Trimpex and Proloprim are brand names that have been discontinued in the US.
Is Primsol (trimethoprim) available as a generic drug?
Do I need a prescription for Primsol (trimethoprim)?
What are the uses for Primsol (trimethoprim)?
- Primsol is used for the treatment of uncomplicated urinary tract infections (UTI) due to susceptible bacteria such as Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter species, and coagulase-negative Staphylococcus species, including S. saprophyticus.
What are the side effects of Primsol (trimethoprim)?
The most common side effects associated with Primsol involve the gastrointestinal (GI) tract, such as:
Other important side effects are:
Serious side effects include:
- Serious allergic reactions
- Exfoliative dermatitis
- Stevens-Johnson syndrome
- Cholestatic jaundice
- C. Difficile diarrhea
Primsol may cause anemia due to a deficiency of folic acid. The anemia usually is mild and resolves when the Primsol is stopped. Patients who are folate-deficient, such as malnourished, alcoholic, geriatric, or pregnant females, may be at greater risk for developing anemia with Primsol. Warning signs of anemia include white or bluish fingernails and unusual tiredness and weakness. Prolonged therapy can result in low platelet counts, low white blood cell counts, and other toxic effects on the blood cells.
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