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February 10, 2012
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trimethobenzamide-rectal, Tigan, Triban

Discontinued Warning Icon Please Note: This Drug will no longer be available in the U.S. after May 9, 2007

GENERIC NAME: TRIMETHOBENZAMIDE - RECTAL (try-meth-oh-BENZ-uh-mide)

BRAND NAME(S): Tigan, Triban

Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage

USES: This medication is used to control nausea and vomiting.

HOW TO USE: Unwrap the suppository and insert it gently but completely into the rectum, pointed-end first. Avoid excessive handling of the suppository so that it doesn't melt before use. This medication is usually used three to four times a day. Use it exactly as prescribed. Do not increase your dose or use this drug more often than directed.

SIDE EFFECTS: Dizziness, drowsiness or headache may occur. If any of these effects continue or become bothersome, inform your doctor. Notify your doctor if you develop: jaundice (e.g., yellowing of the eyes or skin, dark urine), blurred vision, mental confusion, muscle cramps, skin rash. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor your medical history, especially of: high fever, stomach problems (gastroenteritis), swelling/disease of the brain (encephalitis/encephalopathy), mineral (electrolyte) imbalance, any allergies. Do not give children trimethobenzamide to treat vomiting when the cause of vomiting is unknown. Trimethobenzamide may worsen Reye's Syndrome, a rare but serious illness. Do not give trimethobenzamide (or aspirin or acetaminophen) to a child with symptoms of Reye's Syndrome (sudden, severe, persistent vomiting; drowsiness or stupor; unusual behavior; and seizures). Call the doctor immediately if these symptoms are present. Children and teenagers should not use this drug if they have chickenpox, influenza, or any undiagnosed illness without first consulting a doctor about Reye's syndrome. Use caution performing tasks requiring alertness if this medication makes you drowsy or dizzy. Limit alcohol intake because it will add to the dizziness or drowsiness effects of this medication. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this medication is excreted into breast milk. Consult your doctor before breast-feeding.




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trimethobenzamide-rectal, Tigan, Triban

Introduction to nausea and vomiting

Nausea and vomiting are symptoms of an underlying disease and not a specific illness. Nausea is the sensation that the stomach wants to empty itself, while vomiting (emesis) or throwing up, is the act of forcible emptying of the stomach.

Vomiting is a violent act in which the stomach has to overcome the pressures that are normally in place to keep food and secretions within the stomach. The stomach almost turns itself inside out - forcing itself into the lower portion of the esophagus (the tube that connects the mouth to the stomach) during a vomiting episode.

What causes nausea or vomiting?

There are numerous causes of nausea and vomiting. These symptoms may be due to the following:

  • acute gastritis
  • central causes (signals from the brain)
  • association with other illnesses remote from the stomach
  • medications and medical treatments
  • ...

Read the Nausea and Vomiting article »


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