triamterene and hydrochlorothiazide (cont.)

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Salt substitutes (for example, Mrs. Dash) contain potassium and may lead to excessive potassium levels in the body if combined with triamterene/hydrochlorothiazide.

Hydrochlorothiazide increases blood levels of dofetilide (Tikosyn), increasing the adverse effects of dofetilide.

Hydrochlorothiazide reduces the elimination of lithium (Lithobid) by the kidneys, increasing blood levels of lithium and lithium toxicity. Nonsteroidal antiinflammatory drugs, for example, ibuprofen, may reduce the blood pressure-reducing effects of triamterene/hydrochlorothiazide.

Combining hydrochlorothiazide with corticosteroids may increase the risk for low levels of blood potassium and other electrolytes. Low blood potassium can increase the toxicity of digoxin (Lanoxin).

Cholestyramine (Questran, Questran Light) and colestipol (Colestid) bind to hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by 43%-85%.

Blood sugar levels can be elevated by hydrochlorothiazide necessitating adjustment in the doses of medications that are used for treating diabetes.

Medically Reviewed by a Doctor on 10/29/2014

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