triamterene and hydrochlorothiazide (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Cholestyramine (Questran, Questran Light) and colestipol (Colestid) bind to hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by 43%-85%.

Blood sugar levels can be elevated by hydrochlorothiazide necessitating adjustment in the doses of medications that are used for treating diabetes.

PREGNANCY: Triamterene/hydrochlorothiazide has not been adequately studied in pregnant women.

NURSING MOTHERS:  Triamterene/hydrochlorothiazide has not been evaluated in nursing mothers. Hydrochlorothiazide is excreted in breast milk. Intense diuresis using hydrochlorothiazide may reduce the production of breast milk. Otherwise, hydrochlorothiazide is considered safe to use during nursing if required by the mother.

SIDE EFFECTS: Side effects of triamterene/hydrochlorothiazide include abdominal pain, nausea, vomiting, rash, headache, dizziness, constipation, low blood pressure, electrolyte disturbance (for example, high potassium levels), muscle cramps, hypersensitivity, pancreatitis, and jaundice. Triamterene/hydrochlorothiazide may increase blood sugar (glucose) levels and precipitate or worsen diabetes. Patients allergic to sulfa drugs may also be allergic to hydrochlorothiazide because of the similarity in the chemical structure of the two drugs.

Reference: FDA Prescribing Information


Medically Reviewed by a Doctor on 10/29/2014


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