triamterene and hydrochlorothiazide, Maxzide, Dyazide (cont.)

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Medical and Pharmacy Editor:

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 37.5/25, 75/50 mg. Capsules: 37.5/25, 50/25 mg.

STORAGE: Triamterene/hydrochlorothiazide should be store at room temperature, 15-30 C (59-86 F).

PRESCRIBED FOR: Triamterene/hydrochlorothiazide is used for treating high blood pressure and edema.

DOSING: The recommended dose is 1-2 tablets or capsules daily. The maximum dose is 75/50 mg daily. Like other diuretics, it should be taken in the morning in order to avoid excessive trips to the bathroom at night.

DRUG INTERACTIONS: Triamterene increases potassium levels in the body. Therefore, combining triamterene/hydrochlorothiazide with ACE inhibitors [for example, enalapril (Vasotec)], angiotensin receptor blockers [for example, losartan (Cozaar)], aliskiren (Tekturna), eplerenone (Inspra), potassium supplements or other drugs that also increase potassium may lead to dangerous potassium levels in the body.

Salt substitutes (for example, Mrs Dash) contain potassium and may lead to excessive potassium levels in the body if combined with triamterene/hydrochlorothiazide.

Hydrochlorothiazide increases blood levels of dofetilide (Tikosyn), increasing the adverse effects of dofetilide.

Hydrochlorothiazide reduces the elimination of lithium (Lithobid) by the kidneys, increasing blood levels of lithium and lithium toxicity. Nonsteroidal antiinflammatory drugs, for example, ibuprofen, may reduce the blood pressure-reducing effects of triamterene/hydrochlorothiazide.

Blood sugar levels can be elevated by hydrochlorothiazide necessitating adjustment in the doses of medications that are used for treating diabetes.

PREGNANCY: Triamterene/hydrochlorothiazide has not been adequately studied in pregnant women.



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