triamterene and hydrochlorothiazide

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 37.5/25, 75/50 mg. Capsules: 37.5/25, 50/25 mg.

STORAGE: Triamterene/hydrochlorothiazide should be store at room temperature, 15 C - 30 C (59 F - 86 F).

PRESCRIBED FOR: Triamterene/hydrochlorothiazide is used for treating high blood pressure and edema.

DOSING: The recommended dose is 1-2 tablets or capsules daily. The maximum dose is 75/50 mg daily. Like other diuretics, it should be taken in the morning in order to avoid excessive trips to the bathroom at night.

DRUG INTERACTIONS: Triamterene increases potassium levels in the body. Therefore, combining triamterene/hydrochlorothiazide with ACE inhibitors [for example, enalapril (Vasotec)], angiotensin receptor blockers [for example, losartan (Cozaar)], aliskiren (Tekturna), eplerenone (Inspra), potassium supplements or other drugs that also increase potassium may lead to dangerous potassium levels in the body.

Salt substitutes (for example, Mrs. Dash) contain potassium and may lead to excessive potassium levels in the body if combined with triamterene/hydrochlorothiazide.

Hydrochlorothiazide increases blood levels of dofetilide (Tikosyn), increasing the adverse effects of dofetilide.

Hydrochlorothiazide reduces the elimination of lithium (Lithobid) by the kidneys, increasing blood levels of lithium and lithium toxicity. Nonsteroidal antiinflammatory drugs, for example, ibuprofen, may reduce the blood pressure-reducing effects of triamterene/hydrochlorothiazide.

Medically Reviewed by a Doctor on 10/29/2014

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