triamterene and hydrochlorothiazide, Maxzide, Dyazide
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC NAME: triamterene and hydrochlorothiazide (HCTZ)
BRAND NAMES: Maxzide, Dyazide
DRUG CLASS AND MECHANISM: Triamterene/hydrochlorothiazide is an oral diuretic (water pill) that is used for treating high blood pressure (hypertension) and edema (water accumulation). It is a combination of two different diuretics.
The kidneys control the amount of sodium and water within the body. Normally, blood circulates through the kidneys where much of the water, sodium and other small molecules are filtered out of the blood and into the tubules of the kidney. Once in the tubules, much of the water and sodium are reabsorbed back into the blood. The water and sodium that is not reabsorbed passes on through the tubules and becomes urine that is eliminated from the body. Diuretics affect the reabsorption of sodium and water from the tubules and thus, the amount of sodium and water retained or eliminated by the body. In addition to controlling sodium, the kidney also controls the amount of potassium that is retained or eliminated from the body.
Diuretics eliminate salt (sodium) and water from the body. Hydrochlorothiazide is a diuretic that can be used alone for treating high blood pressure and edema. It works by blocking sodium and water reabsorption in the kidneys, thereby reducing sodium and water in the body. (Whereas it is clear how hydrochlorothiazide eliminates water from the body, its mechanism of action in lowering high blood pressure is not well understood.) To compensate for the increased amount of sodium and water in the tubules that will be lost as urine, the kidney tries to reabsorb more sodium and water. It does this by removing potassium from the blood and putting it into the tubules in exchange for sodium (and water) in the tubules. As a result, blood potassium levels fall. Triamterene is a diuretic that prevents reabsorption of sodium in exchange for potassium. Thus, it reduces sodium and water in the body but also prevents the depletion of potassium. For this reason, triamterene is called a potassium sparing diuretic. By combining hydrochlorothiazide with triamterene, sodium and water are eliminated from the body without the loss of potassium.
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets: 37.5/25, 75/50 mg. Capsules: 37.5/25, 50/25 mg.
STORAGE: Triamterene/hydrochlorothiazide should be store at room temperature, 15-30 C (59-86 F).
PRESCRIBED FOR: Triamterene/hydrochlorothiazide is used for treating high blood pressure and edema.
DOSING: The recommended dose is 1-2 tablets or capsules daily. The maximum dose is 75/50 mg daily. Like other diuretics, it should be taken in the morning in order to avoid excessive trips to the bathroom at night.
DRUG INTERACTIONS: Triamterene increases potassium levels in the body. Therefore, combining triamterene/hydrochlorothiazide with ACE inhibitors [for example, enalapril (Vasotec)], angiotensin receptor blockers [for example, losartan (Cozaar)], aliskiren (Tekturna), eplerenone (Inspra), potassium supplements or other drugs that also increase potassium may lead to dangerous potassium levels in the body.
Salt substitutes (for example, Mrs Dash) contain potassium and may lead to excessive potassium levels in the body if combined with triamterene/hydrochlorothiazide.
Hydrochlorothiazide increases blood levels of dofetilide (Tikosyn), increasing the adverse effects of dofetilide.
Hydrochlorothiazide reduces the elimination of lithium (Lithobid) by the kidneys, increasing blood levels of lithium and lithium toxicity. Nonsteroidal antiinflammatory drugs, for example, ibuprofen, may reduce the blood pressure-reducing effects of triamterene/hydrochlorothiazide.
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