trazodone, Desyrel (discontinued brand) (cont.)

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Medical and Pharmacy Editor:
Medical and Pharmacy Editor:

SIDE EFFECTS: The most common side effects associated with trazodone are:

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 50, 100, 150, and 300 mg; Tablets (Extended Release): 150 and 300 mg.

STORAGE: Store at room temperature, 15 C to 30 C (59 F to 86 F)

Priapism, (including clitoral priapism in women) a painful condition in which the penis (or clitoris) remains in an erect position for a prolonged period, has been reported in patients receiving trazodone. Priapism occasionally results in permanent impairment of erectile function or impotence. Patients should be warned of the possibility of priapism and told to discontinue the drug at once and consult with their physician if this reaction occurs. Trazodone also may affect ejaculation, orgasm and libido.

Antidepressants increased the risk of suicidal thinking and behavior (suicidality) in short-term studies in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of trazodone or any other antidepressant in a child or adolescent must balance this risk with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidality, or unusual changes in behavior.

DOSING:

For the treatment of depression, the dose for adults is 150-600 mg per day of regular tablets.

  • The initial starting dose usually is 150 mg per day which is increased by 50 mg/day every 3-7 days.
  • Trazodone regular tablets are given in one or more daily doses, sometimes with the largest dose at night.
  • The dose of extended release tablets are 150 mg at bedtime initially which is increased by 75 mg/day every 3 days. Extended release tablets should be swallowed whole and not crushed or chewed. The maximum dose is 375 mg daily.
  • As with all antidepressants, it may take several weeks for the full effects of treatment to be seen. Doses often are adjusted slowly upwards to find the optimal dose.
  • Elderly patients and debilitated persons may need lower doses.
  • Trazodone should be taken after a meal or light snack to reduce the risk of dizziness. Food also increases the amount of drug absorbed into the body.
Medically Reviewed by a Doctor on 3/27/2015


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