- What is trazodone, and how does it work (mechanism of action)?
- Is trazodone available as a generic drug?
- Do I need a prescription for trazodone?
- What are the side effects of trazodone?
- What is the dosage for trazodone?
- Which drugs or supplements interact with trazodone?
- Is trazodone safe to take if I'm pregnant or breastfeeding?
- What else should I know about trazodone?
What is trazodone, and how does it work (mechanism of action)?
Trazodone is an oral antidepressant drug that affects the chemical messengers (neurotransmitters) within the brain that nerves use to communicate with (stimulate) each other. The major neurotransmitters are acetylcholine, norepinephrine, dopamine and serotonin. Many experts believe that an imbalance among the different neurotransmitters is the cause of depression. Although the exact mechanism of action of trazodone is unknown, it probably improves symptoms of depression by inhibiting the uptake of serotonin by nerves in the brain. This results in more serotonin to stimulate other nerves. Trazodone also may increase directly the action of serotonin. Trazodone is chemically unrelated to the selective serotonin reuptake inhibitors (SSRIs), the tricyclic antidepressants (TCAs) or the monoamine oxidase inhibitors (MAO inhibitors). It is chemically related to nefazodone (Serzone) and shares its actions. Trazodone was approved by the FDA in 1982.
Is trazodone available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for trazodone?
What are the side effects of trazodone?
The most common side effects associated with trazodone are:
- dry mouth,
- low blood pressure,
- blurred vision, and
Quick GuidePhysical Symptoms of Depression in Pictures
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