trastuzumab, Herceptin (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
SIDE EFFECTS: The most common side effects of trastuzumab are:
More patients experience these side effects when trastuzumab is given in combination with paclitaxel. Back pain may occur in 22% of patients receiving trastuzumab alone. More serious but less-common side effects may develop if trastuzumab is given with paclitaxel and other chemotherapeutic drugs, for example, cyclophosphamide (Cytoxan) or doxorubicin (Rubex). Damage to the heart including congestive heart failure (CHF) or ventricular dysfunction may occur in 19% of patients receiving trastuzumab with another chemotherapeutic drug in contrast to 2% to 20% of patients receiving only one of the drugs. Trastuzumab also causes serious and fatal pulmonary toxicity.
Other important side effects of trastuzumab alone or combined with paclitaxel include:
GENERIC AVAILABLE: No
PREPARATIONS: Trastuzumab is available as a powder in a vial containing 440 mg of drug. It must be mixed with a liquid before intravenous injection.
STORAGE: Trastuzumab should be stored at 2 C to 8 C (36 F to 46 F) and should not be frozen.
Medically Reviewed by a Doctor on 7/27/2015
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