trastuzumab, Herceptin (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
PRESCRIBED FOR: Trastuzumab is used to treat metastatic breast cancer or metastatic gastric or gastroesophageal junction adenocarcinoma among patients who overexpress HER2. It may be used alone or combined with other chemotherapeutic drugs.
DOSING: Trastuzumab is administered intravenously. When combined with other drugs for treatment of breast cancer the dose is 4 mg per kilogram of body weight followed by a weekly dose of 2 mg per kilogram of body weight. When used alone for treatment of breast cancer or for treatment of gastric cancer the dose is 8 mg/kg initially followed by 6 mg/kg every 3 weeks.
DRUG INTERACTIONS: Paclitaxel may increase blood levels of trastuzumab.
PREGNANCY: Trastuzumab can cause fetal harm when administered to pregnant women and should not be administered during pregnancy.
NURSING MOTHERS: It is not known whether trastuzumab is excreted in human milk. Nursing mothers should decide whether to stop nursing or discontinue trastuzumab.
SIDE EFFECTS: The most common side effects of trastuzumab are diarrhea (25% of patients), a prickling or burning sensation in the skin (9% of patients), either an upper respiratory or a catheter related infection (26% of patients), increased cough (26% of patients), nausea and vomiting (23-33% of patients), rash (18% of patients), and infusion related side effects including mild to moderate chills and/or fever (40% of patients). More patients experience these side effects when trastuzumab is given in combination with paclitaxel. Back pain may occur in 22% of patients receiving trastuzumab alone. More serious but less-common side effects may develop if trastuzumab is given with paclitaxel and other chemotherapeutic drugs, for example, cyclophosphamide (Cytoxan) or doxorubicin (Rubex). Damage to the heart including congestive heart failure (CHF) or ventricular dysfunction may occur in 19% of patients receiving trastuzumab with another chemotherapeutic drug in contrast to 2% to 20% of patients receiving only one of the drugs. Trastuzumab also causes serious and fatal pulmonary toxicity. Other less-common side effects of trastuzumab alone or combined with paclitaxel include decreased red and/or white blood cells, increased heart rate, body swelling, acne, and herpes simplex infections.
Reference: FDA Prescribing Information
Last Editorial Review: 3/6/2013
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