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- What is trandolapril, and how does it work (mechanism of action)?
- What brand names are available for trandolapril?
- Is trandolapril available as a generic drug?
- Do I need a prescription for trandolapril?
- What are the side effects of trandolapril?
- What is the dosage for trandolapril?
- Which drugs or supplements interact with trandolapril?
- Is trandolapril safe to take if I'm pregnant or breastfeeding?
- What else should I know about trandolapril?
What is trandolapril, and how does it work (mechanism of action)?
Trandolapril is an oral drug that is used to treat high blood pressure. It belongs to a class of drugs called angiotensin converting enzyme (ACE) inhibitors. Other ACE inhibitors include enalapril (Vasotec), captopril (Capoten), lisinopril (Zestril; Prinivil), benazepril (Lotensin), ramipril (Altace), and quinapril (Accupril). Blood pressure is dependent on the degree of constriction (narrowing) of the arteries and veins; the narrower the arteries and veins, the higher the blood pressure. Angiotensin II is a chemical substance made in the body that causes the muscles in the walls of arteries and veins to contract, narrowing the arteries and veins and thereby elevating blood pressure. Angiotensin II is formed by ACE. Trandolapril is an inhibitor of ACE and blocks the formation of angiotensin II thereby lowering blood pressure. The drop in blood pressure also means that the heart doesn't have to work as hard because the pressure it must pump blood against is less. The efficiency of a failing heart improves, and the output of blood from the heart increases. Thus, ACE inhibitors such as trandolapril in addition to high blood pressure, are also useful in treating heart failure. Trandolapril was approved by the FDA in 1996.
What brand names are available for trandolapril?
Is trandolapril available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for trandolapril?
What are the side effects of trandolapril?
Trandolapril is generally well tolerated. The most common side effects are:
- sexual dysfunction, and
- abnormal liver tests.
Impairment of kidney function has been reported with ACE inhibitors, especially in patients with severe heart failure or pre-existing kidney disease. In rare instances, low white blood cell counts have been reported with the use of trandolapril. Low white blood cells increase the risk of infections. Trandolapril may cause hypersensitivity reactions and angioedema (swelling of face, lips, tongue, throat).
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