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trandolapril/verapamil extended-release - oral, Tarka (cont.)

DRUG INTERACTIONS: See also Precautions section.Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.This drug should not be used with the following medication because very serious interactions may occur: dofetilide.If you are currently using the medication listed above, tell your doctor or pharmacist before starting this product.Before using this medication, it is important to tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: aliskiren, disopyramide, gold injections, lithium, drugs that may increase your potassium level (including drospirenone, potassium-sparing "water pills"/diuretics such as spironolactone).Other medications can affect the removal of verapamil from your body, which may affect how this product works. Examples include atorvastatin, phenobarbital, rifamycins (such as rifampin), St. John's wort, among others.Verapamil can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include buspirone, carbamazepine, eplerenone, erythromycin, midazolam, certain drugs for organ transplant (cyclosporine, sirolimus, tacrolimus), certain "statin" drugs (lovastatin, simvastatin), temsirolimus, theophylline, tizanidine, triazolam, among others.A very serious reaction may occur if you are getting injections for bee/wasp sting allergy (desensitization) and are also taking trandolapril/verapamil. Make sure all your doctors know which medicines you are using.Check the labels on all your medicines (such as cough-and-cold products, diet aids, nonsteroidal anti-inflammatory drugs-NSAIDs such as ibuprofen for pain/fever reduction) because they may contain ingredients that could increase your blood pressure or heart rate. Ask your pharmacist about using those products safely.Some nonprescription medicines may also contain aspirin, which may decrease the effect of the trandolapril in this product. If your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.



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