tramadol and acetaminophen, Ultracet (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Because tramadol is chemically related to the narcotic class of drugs such as morphine and hydrocodone (Vicodin ES, Anexsia, Lorcet, Lorcet Plus, Norco), it can cause psychological or physical dependence. Some patients who received tramadol have reported seizures.

Abrupt withdrawal of tramadol may result in the following side effects:

An overdose of acetaminophen can result in severe liver damage.

GENERIC: Yes

PRESCRIPTION: Yes

PREPARATIONS: Tablets: tramadol, 37.5 mg and acetaminophen, 325 mg.

DOSING: The usual dose of Ultracet is two tablets every four to six hours as needed for the relief of pain. Patients should not take more than two tablets at a time nor more than 8 tablets per day.

DRUG INTERACTIONS: Carbamazepine (Tegretol) or rifampin can increase the rate of metabolic breakdown of tramadol, thus making tramadol less effective. Concomitant administration of quinidine, fluoxetine (Prozac), paroxetine (Paxil) and amitriptyline (Elavil, Endep), ketoconazole (Nizoral, Extina, Xolegel, Kuric), or erythromycin may reduce elimination of tramadol, increasing the risk for serious side effects from tramadol.

Medically Reviewed by a Doctor on 1/28/2015


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