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February 10, 2012

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  • Related Diseases & Conditions

    • Rheumatoid Arthritis
      • Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Because it can affect multiple other organs of the body, rheumatoid arthritis is referred to as a systemic illness and is sometimes called rheumatoid disease.
    • Knee Pain
      • The knee joint is composed of three compartments and ligaments which stabilize the joint. Causes of knee pain may include injury, degeneration, infrequently infection and rarely bone tumors. Although routine x-rays do not revel meniscus tears, they can be used to exclude other problems of the bones and tissues. The knee joint is the most commonly involved joint in rheumatic disease, as well as immune diseases that affect various tissues of the body.
    • Osteoarthritis
      • Osteoarthritis is a type of arthritis caused by inflammation, breakdown, and eventual loss of cartilage in the joints. Also known as degenerative arthritis. Osteoarthritis can be caused by aging, heredity, and injury from trauma or disease.
    • Aseptic Necrosis
      • Aseptic necrosis (avascular necrosis or osteonecrosis) is a condition that develops when blood supply diminishes to an area of bone and causes bone death. Though aseptic necrosis may be painless, pain is often associated when the degenerating bone is used. If caught early, aseptic necrosis may be treated by grafting new bone into the degenerating area. In later stages, joint replacement surgery may be required.
    • Malignant Hyperthermia
      • Malignant hyperthermia is a severe reaction to certain drugs that are often used during invasive procedures or surgery. Certain mutations in genes increase the risk of a person having malignant hyperthermia. Without prompt treatment, the complications of malignant hyperthermia can be life-threatening.
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Total Knee Replacement

Malignant hyperthermia facts

*Malignant hyperthermia facts Medically Edited by: Melissa Conrad Stöppler, MD

  • Malignant hyperthermia is a severe reaction to particular drugs that are often used during general anesthesia for surgery.
  • Malignant hyperthermia occurs in 1 in 5,000 to 50,000 instances in which people are given anesthetic gases.
  • Muscle rigidity, breakdown of muscle fibers (rhabdomyolysis), a high fever, increased acid levels in the blood and other tissues (acidosis), and a rapid heart rate are some of the effects of this potentially life-threatening condition.
  • Researchers have described at least six forms of malignant hyperthermia susceptibility, which are caused by mutations in different genes. For example, variations of the CACNA1S and RYR1 genes increase the risk of developing malignant hyperthermia.
  • Malignant hyperthermia susceptibility is inherited in an autosomal dominant manner (which means that one c...

Read the Malignant Hyperthermia article »




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