topiramate, Topamax (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Topiramate also is approved for the prevention of migraine headaches in adults.

SIDE EFFECTS: The most common side effects of topiramate are:

  • tiredness,
  • dizziness,
  • coordination problems,
  • nervousness,
  • nausea,
  • weight loss,
  • confusion,
  • speech problems,
  • changes in vision or
  • double vision,
  • tingling or prickling sensation in hands and feet,
  • difficulty with memory, and
  • sensory distortion.

Other important side effects include:

  • increased ammonia levels,
  • metabolic acidosis,
  • kidney stones,
  • decreased sweating, and
  • increased body temperature.

WARNING: Topiramate may cause sudden onset of vision and eye problems. Symptoms typically occur within the first month of therapy, with patients reporting an acute onset of decreased vision and/or eye pain. Eye examination revealed myopia (nearsightedness), redness, decreased depth of the anterior chamber of the eye and elevated ocular pressure, with or without dilation of the pupils. Fluid accumulation within the eye may displace the lens and iris anteriorly causing secondary angle closure glaucoma. If patients develop this syndrome, the treatment is to discontinue topiramate as rapidly as possible, according to the judgment of the treating physician.

Antiepileptic medications have been associated with increased risk of suicidal thinking and behavior. Anyone considering the use of antiepileptic drugs must balance this risk of suicide with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidal thoughts, or unusual changes in behavior.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 25, 50, 100, 200 mg. Sprinkle capsules: 15 and 25 mg.

STORAGE: Topiramate tablets should be stored at room temperature, 15 C to 30 C (59F to 86 F). Sprinkle capsules should be stored at or below 25 C (77 F).

Medically Reviewed by a Doctor on 12/26/2014


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