tolterodine, Detrol, Detrol LA (cont.)

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PREPARATIONS: Tablets: 1 and 2mg. Long acting capsules: 2 and 4 mg.

STORAGE: Tablets and capsules should be stored at room temperature, 15- 30 C (59-86 F).

PRESCRIBED FOR: Tolterodine is used to treat uncontrollable urination due to what is often referred to as an overactive bladder or urge incontinence. Symptoms include the need to urinate frequently, an urge to urinate immediately, and an inability to control the release of (urinary incontinence).

DOSING: Tolterodine usually is taken twice daily. The starting dose is 1 or 2 mg twice daily. The starting dose when using long-acting tolterodine is 2 or 4 mg daily. The dose may need to be reduced for patients who have impaired liver or kidney function.

DRUG INTERACTIONS: Tolterodine is broken down by liver enzymes before elimination from the body. Drugs that block these liver enzymes may slow the elimination of tolterodine, raise tolterodine blood levels, and lead to side effects. The list of drugs that may interfere with the elimination of tolterodine includes erythromycin, clarithromycin (Biaxin), ketoconazole (Nizoral), itraconazole (Sporanox), cyclosporine, vinblastine, and miconazole (Monistat, Micatin). The dose of tolterodine should be reduced to 1 mg twice daily if taken with any of these drugs.

PREGNANCY: At doses much greater than those used in humans, tolterodine causes fetal abnormalities in animals, but there are no studies with tolterodine in pregnant women. Therefore, tolterodine should only be given to pregnant women if the benefits are felt to outweigh the potential risks.

NURSING MOTHERS: Tolterodine is secreted into breast milk in animals; however, it is not known if tolterodine is secreted into the breast milk of women. Therefore, nursing mothers should either not breast feed or discontinue tolterodine.

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