tolterodine, Detrol, Detrol LA (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
PRESCRIBED FOR: Tolterodine is used to treat uncontrollable urination due to what is often referred to as an overactive bladder or urge incontinence. Symptoms include the need to urinate frequently, an urge to urinate immediately, and an inability to control the release of (urinary incontinence).
SIDE EFFECTS: The most common side effects of tolterodine are:
Tolterodine also may cause blurred vision. Caution is recommended for patients with narrow-angle glaucoma, obstruction to the flow of urine, or poor emptying of the stomach since tolterodine may worsen these medical conditions.
GENERIC AVAILABLE: No
PREPARATIONS: Tablets: 1 and 2mg. Long acting capsules: 2 and 4 mg.
STORAGE: Tablets and capsules should be stored at room temperature, 15 C - 30 C (59 F - 86 F).
DOSING: Tolterodine usually is taken twice daily. The starting dose is 1 or 2 mg twice daily. The starting dose when using long-acting tolterodine is 2 or 4 mg daily. The dose may need to be reduced for patients who have impaired liver or kidney function.
DRUG INTERACTIONS: Tolterodine is broken down by liver enzymes before elimination from the body. Drugs that block these liver enzymes may slow the elimination of tolterodine, raise tolterodine blood levels, and lead to side effects. The list of drugs that may interfere with the elimination of tolterodine includes erythromycin, clarithromycin (Biaxin), ketoconazole (Nizoral), itraconazole (Sporanox), cyclosporine, vinblastine, and miconazole (Monistat, Micatin). The dose of tolterodine should be reduced to 1 mg twice daily if taken with any of these drugs.
Medically Reviewed by a Doctor on 3/30/2015
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