tolmetin, Tolectin (Discontinued Brand) (cont.)

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Medical and Pharmacy Editor:

Persons who have more than three alcoholic beverages per day are at increased risk of developing stomach ulcers when taking tolmetin or other NSAIDs.

PREGNANCY: Tolmetin is generally avoided during pregnancy.

NURSING MOTHERS: Tolmetin is excreted in breast milk. To avoid adverse effects in the infant, nursing mothers should decide whether to stop nursing or stop tolmetin.

SIDE EFFECTS: Most patients benefit from tolmetin and other NSAIDs with few side effects. However, serious side effects can occur, and generally tend to be dose related. Therefore, it is advisable to use the lowest effective dose to minimize side effects. The most common side effects of tolmetin involve the gastrointestinal system. It can cause ulcerations, abdominal pain, cramping, nausea, gastritis, and even serious gastrointestinal bleeding, and liver toxicity. Sometimes, stomach ulceration and bleeding can occur without any abdominal pain. Black tarry stools, weakness, and dizziness upon standing may be the only signs of internal bleeding. Rash, ringing in the ears, and lightheadedness also can occur.

Tolmetin should be avoided by patients with a history of asthma, hives, or other allergic reactions to aspirin or other NSAIDs. Rare but severe allergic reactions have been reported in such individuals. It also should be avoided by patients with peptic ulcer disease or poor kidney function, since this medication can aggravate both conditions.

Like other NSAIDS tolmetin may cause heart attacks and strokes lead to accumulation of fluid, worsen heart failure, and cause or worsen high blood pressure and kidney failure.

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 9/7/2012

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