tolazamide (Tolinase) (cont.)

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PREPARATIONS: Oral tablets: 100, 250, and 500 mg

STORAGE: Tablets should be stored at room temperature, between 15 C and 30 C (59 F to 86 F).



  • Generally, patients are started on 100 to 250 mg of tolazamide once daily with breakfast or first meal of the day.
  • Start with 100 mg/day for fasting blood sugar <200 mg/dL or 250 mg for fasting blood sugar >200 mg/dL.
  • Use 100 mg/day for patients who are malnourished, underweight, elderly, or those not eating properly.
  • Dosage may be increased by 100-250 mg at weekly intervals.
  • The maximum daily dose is 500 mg orally twice daily (1000mg/day).

The safety and efficacy of tolazamide has not been established in pediatric patients. No specific dose adjustments are recommended in patients with kidney or liver disease.


Coadministration of tolazamide with quinolone antibiotics may cause abnormal changes in blood glucose. Therefore, blood glucose must be closely monitored if these agents must be used together.

Tolazamide may increase blood levels of methotrexate (Rheumatrex, Trexall) by interfering with the binding of methotrexate to blood proteins.

Anti-retroviral protease inhibitors, a type of anti-HIV medication, may decrease the effectiveness of tolazamide and consequently worsen blood glucose control.

PREGNANCY: Tolazamide has not been adequately evaluated in pregnant women. Due to the lack of conclusive safety data, tolazamide should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Tolazamide is classified as FDA pregnancy risk category C.

NURSING MOTHERS: It is not known if tolazamide is excreted in breast milk. Due to the potential risk for hypoglycemia (low blood glucose) in the nursing infant, use of tolazamide is not recommended in nursing mothers.

REFERENCE: FDA Prescribing Information

Medically Reviewed by a Doctor on 8/17/2015

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