tolazamide (Tolinase) (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
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In this Article
GENERIC AVAILABLE: Yes
PREPARATIONS: Oral tablets: 100, 250, and 500 mg
STORAGE: Tablets should be stored at room temperature, between 15 C and 30 C (59 F to 86 F).
The safety and efficacy of tolazamide has not been established in pediatric patients. No specific dose adjustments are recommended in patients with kidney or liver disease.
Coadministration of tolazamide with quinolone antibiotics may cause abnormal changes in blood glucose. Therefore, blood glucose must be closely monitored if these agents must be used together.
Tolazamide may increase blood levels of methotrexate (Rheumatrex, Trexall) by interfering with the binding of methotrexate to blood proteins.
Anti-retroviral protease inhibitors, a type of anti-HIV medication, may decrease the effectiveness of tolazamide and consequently worsen blood glucose control.
PREGNANCY: Tolazamide has not been adequately evaluated in pregnant women. Due to the lack of conclusive safety data, tolazamide should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Tolazamide is classified as FDA pregnancy risk category C.
NURSING MOTHERS: It is not known if tolazamide is excreted in breast milk. Due to the potential risk for hypoglycemia (low blood glucose) in the nursing infant, use of tolazamide is not recommended in nursing mothers.
REFERENCE: FDA Prescribing Information
Medically Reviewed by a Doctor on 8/17/2015
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