BRAND NAME: Tolinase
DRUG CLASS AND MECHANISM: Tolazamide is an oral medication used to treat high blood glucose in patients with type 2 diabetes mellitus. It is a first generation sulfonylurea used in combination with exercise and dietary modifications to lower blood glucose in patients. Tolazamide stimulates the release of insulin from the pancreatic beta cells. Insulin is responsible for regulating how the body uses and stores glucose. It also reduces the production of glucose from the liver and increases the sensitivity of cells throughout the body to insulin. By increasing muslin sensitivity, the cells remove more glucose from the blood. Tolazamide was approved by the FDA in 1965.
Side effects associated with tolazamide therapy include
- increase sensitivity to the sunlight (photophobia),
- disulfiram (Antabuse)-like reactions (for example, severe flushing accompanied by low blood pressure (hypotension) and tachycardia,
- low blood glucose,
- low blood sodium,
- syndrome of inappropriate antidiuretic hormone secretion (SIADH),
- sensations of stomach fullness,
- blood disorders,
- liver dysfunction,
- muscle weakness, and
- water loss from the body (diuresis).
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