Tofacitinib citrate (Xeljanz)

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GENERIC NAME: Tofacitinib citrate

BRAND NAME: Xeljanz

DRUG CLASS AND MECHANISM: Tofacitinib is an oral drug used for treating rheumatoid arthritis. It belongs to a class of drugs called Janus kinase (JAK) inhibitors. JAKs are enzymes (proteins) that regulate chemical signaling pathways that control biologic processes such as blood formation and the immune response response that causes the pain, tenderness and swelling of inflammation. JAKs are found in many cells, especially stem cells in bones and joints. Inhibition of JAKs by tofacitinib prevents inflammation and tissue destruction that is associated with the inflammation of rheumatoid arthritis. Tofacitinib was approved in November 2012.

PRESCRIPTION: Yes

GENERIC AVAILABLE: No

PREPARATIONS: Tofacitinib is available as film-coated, immediate-release, 5 mg tablets.

STORAGE: Tofacitinib should be stored at room temperature between 20 C to 25 C (68 F to 77 F).

PRESCRIBED FOR: Tofacitinib is used for moderate-to-severely active rheumatoid arthritis in adults who have had an insufficient response or cannot tolerate methotrexate (Rheumatrex, Trexall).

Tofacitinib may be used by itself or in combination with methotrexate or other non-biologic disease-modifying anti-rheumatic drugs (DMARDs).

Medically Reviewed by a Doctor on 5/15/2014



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