tobramycin ophthalmic solution (Tobrex)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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GENERIC NAME: tobramycin ophthalmic solution

BRAND NAMES: Tobrex

DRUG CLASS AND MECHANISM: Tobramycin is an aminoglycoside antibiotic that interferes with bacterial production of proteins, ultimately leading to bacterial death. Tobramycin, like other aminoglycoside antibiotics, targets various gram-positive and gram-negative bacteria. Targeted organisms include Staphylococcus aureus, Staphylococcus epidermidis, Streptococci, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, Proteus vulgaris (most strains), Haemophilus influenzae, Haemophilus aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus, and some Neisseria species. The FDA approved tobramycin ophthalmic solution in December 1980.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Ophthalmic Solution 0.3%

STORAGE: Tobramycin ophthalmic solution should be stored at room temperature, between 15 C to 30 C (59 F to 86 F). Some preparations may be refrigerated and stored between 2 C to 8 C (36 F to 46 F).

PRESCRIBED FOR: Tobramycin ophthalmic solution is prescribed for the treatment of bacterial infections of the eye.

DOSING: The initial dose for adults and children two months old or greater is 1 to 2 drops every 2 to 4 hours in the infected eye. For severe infections, up to 2 drops every hour may be used until improvement is seen, at which time the dose should be reduced.

DRUG INTERACTIONS: There are no known drug interactions with tobramycin ophthalmic solution.

PREGNANCY: There is no evidence of harm to the fetus in animal studies with systemic tobramycin use; no direct studies in humans have been conducted. Blood levels are undetectable after ophthalmic tobramycin use.

NURSING MOTHERS: Tobramycin ophthalmic solution is not absorbed into the body at detectable levels, and therefore not expected to be present in the breast milk. However, breast feeding is not recommended due to the potential for adverse effects in the infant.

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