tobramycin optic (Tobrex)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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STORAGE: Tobramycin ophthalmic solution should be stored at room temperature between 20 C and 25 (68 F and 77 F).

PRESCRIBED FOR: Tobramycin ophthalmic solution is used to treat external eye infections caused by susceptible bacteria.

DOSING: For all patients ≥ 2 months of age: Instill 1-2 drops into the infected eye every 4 to 6 hours. For severe infections, instill 2 drops into the infected eye every 30 minutes to an hour until improvement and then reduce to less frequent dosing intervals as indicated. Patients using tobramycin ophthalmic solution:

  • should wash their hands thoroughly with soap and water before and after using eye drops;
  • should be advised not to wear contact lenses during treatment of active eye infections;
  • must take care to avoid touching the dropper tip to the eye while administrating eye drops;
  • should wait for at least 5 minutes between applications if other eye drop preparations also are used.

DRUG INTERACTIONS: Information on possible drug interactions with tobramycin ophthalmic drops is not found. However, as use of therapeutic levels of tobramycin eye drops does not result into clinically meaningful levels of drug in the blood, the potential for drug interaction with other agents is relatively low. Patients using other eye drops or those with pre-existing conditions of the eye should check with their doctor or pharmacists before using tobramycin ophthalmic drops.

PREGNANCY: Use of tobramycin eye drops does not result in clinically meaningful levels of drug in the blood and does not seem to cross the placenta. Therefore, use of tobramycin eye drops during pregnancy is generally considered to be safe. Tobramycin ophthalmic is classified as FDA pregnancy risk category B (Reproduction studies in three types of animals at doses up to thirty-three times the normal human systemic dose have revealed no evidence of impaired fertility or harm to the fetus due to tobramycin. There are, however, no adequate and well-controlled studies in pregnant women. Because animal studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.).

NURSING MOTHERS: Most aminoglycoside antibiotics are excreted into breast milk in low concentrations. The risk for adverse effects in the nursing infant with use of ophthalmic tobramycin is considered to be low. However, consideration of the benefits of breastfeeding, the risk of potential infant drug exposure, and the risk of an untreated or inadequately treated infection should all be taken into account when making the decision to use tobramycin ophthalmic in nursing mothers.

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 6/9/2015
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