tizanidine

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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PREGNANCY AND BREASTFEEDING SAFETY: There are no adequate studies done on tizanidine to determine safe and effective use in pregnant women.

It is not known whether tizanidine enters human milk. Because it is soluble in lipids, it might pass into breast milk.

STORAGE: Store tizanidine tablets and capsules between temperatures of 15 C – 30 C (59 F – 86 F).

DOSAGE: Initially take 2 - 4 mg by mouth every 6 to 8 hours for up to 3 doses in 24 hours. Increase by 2 to 4 mg until satisfactory response is achieved; however, the maximum dose is 36 mg per day.

DRUG CLASS AND MECHANISM: Tizanidine is a skeletal muscle relaxant. It works on alpha2 receptors in the central nervous system (brain and spinal cord) and blocks nerve impulses from reaching muscles which produces muscle relaxation. The FDA approved tizanidine in November 1996.

Medically reviewed by Eni Williams, PharmD, PhD

REFERENCE: FDA Prescribing Information

Medically Reviewed by a Doctor on 7/12/2016

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