tizanidine

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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What is tizanidine-oral, and how does it work (mechanism of action)?

Tizanidine is a skeletal muscle relaxant. It works on alpha2 receptors in the central nervous system (brain and spinal cord) and blocks nerve impulses from reaching muscles which produces muscle relaxation. The FDA approved tizanidine in November 1996.

What brand names are available for tizanidine-oral?

Zanaflex

Is tizanidine-oral available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for tizanidine-oral?

Yes

What are the uses for tizanidine-oral?

Tizanidine is used for the treatment and management of skeletal muscle spasticity. Spasticity may be due to multiple sclerosis or spinal cord injury.

What are the side effects of tizanidine-oral?

Common side effects of tizanidine include:

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What is the dosage for tizanidine-oral?

Initially take 2 - 4 mg by mouth every 6 to 8 hours for up to 3 doses in 24 hours. Increase by 2 to 4 mg until satisfactory response is achieved; however, the maximum dose is 36 mg per day.

Which drugs or supplements interact with tizanidine-oral?

Tizanidine should not be used with:

These medications can slow down the breakdown of tizanidine and lead to increased sedation, drowsiness and slowed reflexes.

Tizanidine should be used with caution with medications like:

These medications can further increase the side effects of tizanidine.

Is tizanidine-oral safe to take if I'm pregnant or breastfeeding?

There are no adequate studies done on tizanidine to determine safe and effective use in pregnant women.

It is not known whether tizanidine enters human milk. Because it is soluble in lipids, it might pass into breast milk.

What else should I know about tizanidine-oral?

What preparations of tizanidine-oral are available?

Capsules: 2, 4, 6 mg; Tablets: 2, 4 mg

How should I keep tizanidine-oral stored?

Store tizanidine tablets and capsules between temperatures of 15 C – 30 C (59 F – 86 F).

REFERENCE: FDA Prescribing Information

Last Editorial Review: 7/12/2016

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Reviewed on 7/12/2016
References
REFERENCE: FDA Prescribing Information

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