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GENERIC NAME: Tizanidine hydrochloride

BRAND NAME: Zanaflex

DRUG CLASS AND MECHANISM: Tizanidine is a skeletal muscle relaxant. It works on alpha2 receptors in the central nervous system (brain and spinal cord) and blocks nerve impulses from reaching muscles which produces muscle relaxation. The FDA approved tizanidine in November 1996.



PREPARATIONS: Capsules: 2, 4, 6 mg; Tablets: 2, 4 mg

STORAGE: Store tizanidine tablets and capsules between temperatures of 15 C – 30 C (59 F – 86 F).

PRESCRIBED FOR: Tizanidine is used for the treatment and management of skeletal muscle spasticity. Spasticity may be due to multiple sclerosis or spinal cord injury.

DOSING: Initially take 2 - 4 mg by mouth every 6 to 8 hours for up to 3 doses in 24 hours. Increase by 2 to 4 mg until satisfactory response is achieved; however, the maximum dose is 36 mg per day.

DRUG INTERACTIONS: Tizanidine should not be used with ciprofloxacin (Cipro), amiodarone (Cordarone), cimetidine (Tagamet), oral contraceptives, acyclovir (Zovirax), and fluvoxamine (Luvox). These medications can slow down the breakdown of tizanidine and lead to increased sedation, drowsiness and slowed reflexes.

Medically Reviewed by a Doctor on 10/13/2014

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