opium tincture (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Respiratory depression and physical and psychological dependence also occur.



PREPARATIONS: Opium tincture is odorless oral liquid containing 10 mg of anhydrous morphine per one ml.

STORAGE: Store tincture of opium at room temperature between 68 F to 77 F (20 C to 25 C).


  • Adults: Take 0.6 ml by mouth 4 times a day not to exceed 6 ml per day.
  • Children: Safe and effective use of opium tincture is not established in children.

DRUG INTERACTIONS: Opium tincture should not be used with medications like naltrexone and buprenorphine because they increase sedation and lower beneficial effect of opium tincture.

Opium tincture contains morphine. Morphine should be avoided in patients treated with monoamine oxidase inhibitors (MAOI) due to enhance toxicity of morphine including confusion, high blood pressure, tremor, hyperactivity, coma, and death. Drugs in this class include isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl), and procarbazine (Matulane), and linezolid (Zyvox). Morphine should not be administered within 14 days of stopping an MAOI.

PREGNANCY: There are no adequate studies done on opium tincture to determine safe and effective use in pregnant women.

NURSING MOTHERS: Opium tincture contains morphine. Morphine is excreted in breast milk; however, the American Academy of Pediatrics committee states that it is safe to use while breastfeeding.

Medically reviewed by Eni Williams, PharmD

REFERENCE: Tincture of Opium Prescribing Information.

Medically Reviewed by a Doctor on 9/14/2015

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