timolol ophthalmic solution (Timoptic, Timoptic-XE, Timoptic in Ocudose)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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PREPARATIONS: Ophthalmic solution: 0.25%, 0.5%. There is also a gel-forming solution (Timoptic-XE) in a 0.25% and 0.5% concentration.

STORAGE: Ophthalmic solution should be kept at room temperature, 15 C - 30 C (59 F - 86 F) and protected for direct light.


  • Both hands should be washed before each use of timolol or any other eye medication.
  • The head should be tilted back and the lower lid pulled down with the index finger to form a pouch.
  • The tip of the dropper should not be touched to the eye or eyelid.
  • The bottle should be squeezed slightly to allow the prescribed number of drops into the pouch.
  • The eye is closed gently for 1 to 2 minutes without blinking.
  • The usual dose is one drop into the affected eye twice daily.
  • Timoptic-XE gel forming solution dose is one drop once per day.

DRUG INTERACTIONS: Combined use of oral beta-adrenergic blocking agents, for example, propranolol (Inderal), atenolol (Tenormin), metoprolol (Lopressor) or carvedilol (Coreg) with ophthalmic timolol can result in additive effects. Thus, patients may experience excessively low blood pressure or reductions in heart rate.

Combining calcium channel blockers or CCBs (for example, diltiazem) with timolol may increase the risk of abnormal heart beats.

Medically Reviewed by a Doctor on 12/10/2014
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