timolol ophthalmic solution, Timoptic

GENERIC NAME: timolol ophthalmic solution

BRAND NAME: Timoptic

DRUG CLASS AND MECHANISM: Timolol is a beta- adrenergic blocking agent. Like other beta-adrenergic blocking agents, it mainly blocks the action of the sympathetic (adrenergic) nervous system, for example, on the heart. In addition to its effect on the heart, timolol causes a reduction of the pressure within the eye (intraocular pressure). This effect is thought to be caused by a reduction in the production of the liquid (aqueous humor) within the eye. The precise mechanism of this effect is not known. The reduction in intraocular pressure reduces the risk of damage to the optic nerve and loss of vision in patients with glaucoma. Timolol was approved by the FDA for ocular use in 1978.

PRESCRIPTION: yes

GENERIC AVAILABLE: yes

PREPARATIONS: Ophthalmic solution: 0.25%, 0.5%. There is also a gel-forming solution (Timoptic-XE) in a 0.25% and 0.5% concentration.

STORAGE: Ophthalmic solution should be kept at room temperature, 15-30°C
(59-86°F) and protected for direct light.

PRESCRIBED FOR: Timolol is used for the treatment of glaucoma. (Oral timolol tablets are used for treating high blood pressure and angina, but this dosage form is not discussed here.)




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