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February 10, 2012
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tiludronate - oral, Skelid

GENERIC NAME: TILUDRONATE - ORAL (till-EW-dro-nate)

BRAND NAME(S): Skelid

Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage

USES: Tiludronate is used to treat a certain type of bone disease called Paget's disease. This disease weakens and deforms bones. Tiludronate works by slowing bone loss, helping to keep your bones strong and less likely to break. It also helps reduce bone pain from this disease. This medication belongs to a class of drugs called bisphosphonates.

HOW TO USE: Follow these instructions very closely to make sure you absorb as much of the drug as possible and reduce the risk of injury to your esophagus. Consult your doctor or pharmacist if you have any questions.Take this medication by mouth without food, usually once a day or as directed by your doctor. Take it on an empty stomach at least 2 hours before or 2 hours after a meal.Take tiludronate with a full glass of plain water (6 to 8 ounces, 180 to 240 milliliters). Do not take it with any other beverage. After taking tiludronate, stay fully upright (sitting, standing, or walking) and do not lie down for at least 30 minutes.Do not take tiludronate at the same time as food or other medications because they may affect its absorption. Take this medication 2 hours before or 2 hours after taking any products that contain aluminum, calcium, iron, magnesium, or zinc. Some examples include certain forms of didanosine (chewable/dispersible buffered tablets or pediatric oral solution), quinapril, vitamins/minerals, dairy products (such as milk, yogurt), and calcium-enriched juice.If you take antacids that contain aluminum or magnesium, take them at least 2 hours after taking tiludronate.If you take aspirin or indomethacin, take the dose 2 hours before or 2 hours after your tiludronate dose.Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day, usually for 3 months or as directed by your doctor.

SIDE EFFECTS: Nausea or diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: new or worsening bone/joint/muscle pain, jaw pain, eye/vision problems.This medication may infrequently cause irritation and ulcers in your stomach or esophagus. Seek immediate medical attention if any of these serious side effects occur: new/severe/worsening heartburn, chest pain, difficult/painful swallowing, stomach/abdominal pain, black/tarry stools, vomit that looks like coffee grounds.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.




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tiludronate - oral, Skelid

What is Paget's disease?

Paget's disease is a chronic condition of bone characterized by disorder of the normal bone remodeling process. Normal bone has a balance of forces that act to lay down new bone and take up old bone. This relationship (referred to as "bone remodeling") is essential for maintaining the normal calcium levels in our blood. In bone affected by Paget's disease, the bone remodeling is disturbed and not synchronized. As a result, the bone that is formed is abnormal, enlarged, not as dense, brittle, and prone to breakage (fracture).

Paget's disease affects older skeletal bone of adults. It's estimated that 1% of adults in the U.S. have Paget's disease. There is also an extremely rare form of Paget's disease in children, referred to as juvenile Paget's disease. Paget's disease is also known as osteitis deformans.

What causes Paget's disease?

It is not known what causes Paget's disease. Recently, certain...

Read the Paget's Disease article »


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